乙基异丙基氨氯吡咪对低浓度哇巴因诱发的大鼠离体心室正性肌力作用的选择性抑制。
Selective inhibition by ethylisopropylamiloride of the positive inotropic effect evoked by low concentrations of ouabain in rat isolated ventricles.
作者信息
Finet M, Godfraind T
出版信息
Br J Pharmacol. 1986 Nov;89(3):533-8. doi: 10.1111/j.1476-5381.1986.tb11153.x.
Abstract
The biphasic positive inotropic effect of ouabain has been studied in rat ventricular strips in the presence of ethylisopropylamiloride (EIPA) an inhibitor of Na+/H+ exchange. EIPA (10-20 microM) depressed dose-dependently the high affinity component of the ouabain inotropic effect, whereas it did not significantly modify the low affinity inotropic effect related to high concentrations of ouabain. At the EIPA concentrations studied, there was no observable modification of the inotropic effect of Bay K 8644 (10 nM, 0.3 microM) or of isoprenaline (10 nM, 1 microM). These results indicate that the inotropic effect of ouabain resulting from its interaction with high affinity sites is selectively sensitive to EIPA.
摘要
在存在钠氢交换抑制剂乙基异丙基amiloride（EIPA）的情况下，对哇巴因在大鼠心室肌条中的双相正性肌力作用进行了研究。EIPA（10 - 20微摩尔）剂量依赖性地降低了哇巴因正性肌力作用的高亲和力成分，而对与高浓度哇巴因相关的低亲和力正性肌力作用没有显著影响。在所研究的EIPA浓度下，未观察到Bay K 8644（10纳摩尔，0.3微摩尔）或异丙肾上腺素（10纳摩尔，1微摩尔）的正性肌力作用有改变。这些结果表明，哇巴因与高亲和力位点相互作用产生的正性肌力作用对EIPA具有选择性敏感性。
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本文引用的文献
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