Department of Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah-Tiqva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Clin Microbiol Infect. 2014 Feb;20(2):101-4. doi: 10.1111/1469-0691.12497.
As in other disciplines in medicine, systematic reviews (SR) and meta-analyses (MA) in infectious diseases are an important aid to clinical decision-making. In the present article we review features important to SRs in infectious diseases that should be addressed in most SRs and MAs. We stress the need to include in the SR analysis all patients that were randomized; and all studies that were performed. Authors of SRs should choose one main outcome that matters to patients, and base their conclusions mainly on this outcome. Resistance as an outcome is a topic that should be addressed in all SRs of antibiotic treatment. Ethical aspects and especially patients' safety should be addressed in SRs.
与医学其他学科一样，传染病领域的系统评价（SR）和荟萃分析（MA）也是临床决策的重要辅助手段。本文回顾了传染病领域 SR 和 MA 中最重要的特点，这些特点应在大多数 SR 和 MA 中得到体现。我们强调，SR 分析中应纳入所有随机分组的患者和所有开展的研究。SR 作者应选择一个对患者重要的主要结局，并主要基于该结局得出结论。耐药性作为一个结局，应该在所有抗生素治疗的 SR 中得到体现。SR 中应涉及伦理问题，特别是患者安全问题。
