白藜芦醇可诱导小鼠胰岛α细胞胰岛素基因的表达。
Resveratrol induces insulin gene expression in mouse pancreatic α-cells.
机构信息
Laboratory of Hormonal Regulation, Program of Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, 8 College Road, Singapore, Singapore.
Department of Clinical Research, Singapore General Hospital, Singapore 169857, Singapore.
出版信息
Cell Biosci. 2013 Dec 13;3(1):47. doi: 10.1186/2045-3701-3-47.
BACKGROUND
Type 1 and type 2 diabetes are characterized by loss of β-cells; therefore, β-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic compound, has been shown to improve glycaemic control in diabetic patients, but its action on pancreatic α-cells is not well understood.
FINDINGS
Using mouse α-cells (αTC9), we showed that resveratrol induces expression of pancreatic β-cell genes such as Pdx1 and Ins2 in a SirT1-dependent manner. The mRNA and protein levels of insulin were further increased by histone deacetylase (HDAC) inhibition.
CONCLUSION
In summary, we provide new mechanistic insight into the anti-diabetic action of resveratrol through its ability to express β-cell genes in α-cells.
背景
1 型和 2 型糖尿病的特征是β细胞丧失；因此，β细胞再生已成为糖尿病治疗的主要方法之一。白藜芦醇是一种天然存在的多酚化合物，已被证明可改善糖尿病患者的血糖控制，但人们对其对胰腺α细胞的作用了解甚少。
结果
我们使用小鼠α细胞（αTC9）表明，白藜芦醇以 SirT1 依赖的方式诱导胰腺β细胞基因如 Pdx1 和 Ins2 的表达。组蛋白去乙酰化酶（HDAC）抑制进一步增加了胰岛素的 mRNA 和蛋白水平。
结论
总之，我们通过白藜芦醇在α细胞中表达β细胞基因的能力，为其抗糖尿病作用提供了新的机制见解。
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