Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Faculty of Nutrition Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Obes Res Clin Pract. 2011 Jul-Sep;5(3):e169-266. doi: 10.1016/j.orcp.2011.03.003.
To study the effects of a 12-week continuous aerobic exercise program without energy restriction on intrahepatic fat, indices of liver function (aspartate aminotransferase [AST], alanine aminotransferase [ALT] and γ-glutamyl transpeptidase [γGTP]), plasminogen activator inhibitor-1 (PAI-1) and insulin resistance (HOMA-IR).
Subjects were divided into two groups based on the degree of intrahepatic fat accumulation at baseline (high liver fat [HLF]: n = 13; low liver fat [LLF]: n = 14). Participants were instructed to exercise for more than 300 min per week at the lactate threshold. Fat accumulation (intramuscular, intrahepatic, visceral and subcutaneous fat) was evaluated by computed tomography. Blood samples were taken to determine the levels of AST, ALT, PAI-1, glucose and insulin.
Weight, body mass index, body fat, visceral fat and subcutaneous fat decreased significantly in both groups between baseline and post-intervention (P < 0.05), but were not significantly different between the two groups (P > 0.05). Intrahepatic fat, AST, ALT and PAI-1 improved significantly between baseline and post-intervention in the HLF group (P < 0.05; AST, P = 0.052), and improvements were significantly greater than those in the LLF group (P < 0.05). γGTP decreased significantly in the HLF group between baseline and post-intervention (P < 0.05), but was not significantly different between the two groups (P > 0.05). HOMA-IR did not significantly improve between baseline and post-intervention either within or between the two groups (P > 0.05).
This study revealed that a 12-week continuous aerobic exercise program without energy restriction might improve intrahepatic fat, liver function and atherosclerosis-related factors.
研究 12 周无能量限制的连续有氧运动方案对肝内脂肪、肝功能指标（天冬氨酸氨基转移酶[AST]、丙氨酸氨基转移酶[ALT]和γ-谷氨酰转肽酶[γGTP]）、纤溶酶原激活物抑制剂-1（PAI-1）和胰岛素抵抗（HOMA-IR）的影响。
根据基线时肝内脂肪堆积程度（高肝脂肪[HLF]：n=13；低肝脂肪[LLF]：n=14）将受试者分为两组。指导参与者每周在乳酸阈下进行超过 300 分钟的运动。通过计算机断层扫描评估脂肪堆积（肌肉内、肝内、内脏和皮下脂肪）。采集血样以确定 AST、ALT、PAI-1、葡萄糖和胰岛素水平。
两组的体重、体重指数、体脂、内脏脂肪和皮下脂肪在基线和干预后均显著下降（P<0.05），但两组间无显著差异（P>0.05）。HLF 组的肝内脂肪、AST、ALT 和 PAI-1 从基线到干预后显著改善（P<0.05；AST，P=0.052），且改善幅度明显大于 LLF 组（P<0.05）。HLF 组的γGTP 在基线和干预后显著下降（P<0.05），但两组间无显著差异（P>0.05）。HOMA-IR 在两组内和组间从基线到干预后均无显著改善（P>0.05）。
本研究表明，12 周无能量限制的连续有氧运动方案可能改善肝内脂肪、肝功能和动脉粥样硬化相关因素。
