Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Cancer Cell. 2013 Dec 9;24(6):687-9. doi: 10.1016/j.ccr.2013.11.014.
Macrophages infiltrate hypoxic tumor regions, where they promote angiogenesis and immunosuppression. In this issue of Cancer Cell, Casazza and colleagues report that tumor-associated macrophage (TAM) entry into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with this pathway entraps TAMs in oxygenated areas, preventing their tumorigenic function.
巨噬细胞浸润到低氧肿瘤区域,在那里它们促进血管生成和免疫抑制。在本期《癌细胞》中,Casazza 及其同事报告称,肿瘤相关巨噬细胞(TAM)进入无血管肿瘤区域受信号素 3A/神经纤毛蛋白 1 的调节;干扰该途径会将 TAMs 困在富含氧的区域,从而阻止它们的肿瘤发生功能。