The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Cancer Cell. 2013 Mar 18;23(3):277-86. doi: 10.1016/j.ccr.2013.02.013.
Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also shown that TAMs can either enhance or antagonize the antitumor efficacy of cytotoxic chemotherapy, cancer-cell targeting antibodies, and immunotherapeutic agents--depending on the type of treatment and tumor model. TAMs also drive reparative mechanisms in tumors after radiotherapy or treatment with vascular-targeting agents. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target TAMs to increase the efficacy of such therapies.
肿瘤相关巨噬细胞（TAMs）促进肿瘤进展中的关键过程，如血管生成、免疫抑制、侵袭和转移。越来越多的研究还表明，TAMs 可以增强或拮抗细胞毒性化疗、癌细胞靶向抗体和免疫治疗药物的抗肿瘤疗效——这取决于治疗类型和肿瘤模型。TAMs 还在放疗或血管靶向药物治疗后驱动肿瘤中的修复机制。在这里，我们讨论了这些发现的生物学意义和临床意义，重点介绍了有效靶向 TAMs 以提高这些疗法疗效的新方法。
