Smyth Alan R, Campbell Emma L
Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.
Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.
J Cyst Fibros. 2014 Jul;13(4):424-7. doi: 10.1016/j.jcf.2013.11.007. Epub 2013 Dec 11.
Intravenous aminoglycoside antibiotics are widely used to treat pulmonary infection with Pseudomonas aeruginosa in individuals with cystic fibrosis (CF). Over the last decade evidence has accumulated showing that the choice of aminoglycoside and the dosing regimen may help reduce adverse effects such as nephrotoxicity.
We undertook an online survey to determine current practice in UK CF Centres.
We received a response from 35/48 (73%) centres. A once daily regimen was used in 30/35 (86%) centres. Around one third had stopped using gentamicin in the last 10 years. In most cases respondents reported changing practice in response to new evidence or evidence based guidelines. Obstacles to introducing evidence based practice were identified both at the level of the CF Centre and the hospital trust.
A once daily aminoglycoside regimen is now used in the majority of UK CF Centres. Tobramycin is first line and many centres have stopped using gentamicin. Obstacles to evidence based practice remain in a minority of centres.
静脉注射氨基糖苷类抗生素被广泛用于治疗囊性纤维化（CF）患者的铜绿假单胞菌肺部感染。在过去十年中，越来越多的证据表明，氨基糖苷类药物的选择和给药方案可能有助于减少诸如肾毒性等不良反应。
我们进行了一项在线调查，以确定英国CF中心的当前做法。
我们收到了48个中心中35个（73%）的回复。35个中心中有30个（86%）采用每日一次的给药方案。在过去10年里，约三分之一的中心已停止使用庆大霉素。在大多数情况下，受访者表示根据新证据或循证指南改变了做法。在CF中心和医院信托层面都发现了引入循证实践的障碍。
目前英国大多数CF中心采用每日一次的氨基糖苷类给药方案。妥布霉素是一线用药，许多中心已停止使用庆大霉素。少数中心仍然存在循证实践的障碍。
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