Pizzichini M, Di Stefano A, Marinello E
Ital J Biochem. 1986 Sep-Oct;35(5):347-54.
Nucleid acid metabolism in the LAM of the rat, both before and after castration, and during testosterone treatment, was investigated. RNA synthesis was increased by testosterone treatment, to varying degree, in adult and in prepubertal castrated rats, and was not merely dependent on the degree of hypertrophy of the LAM. The DNA content and the incorporation rate of formate-14C into DNA showed a characteristic profile under the same conditions: the atrophy of LAM following castration and its subsequent restoration appeared to be accompanied by variations in nuclei number. The possible role of testosterone in DNA duplication and in cell mitosis is hypothesized here; further investigation must be integrated by careful morphometric observation.
对大鼠去势前后以及睾酮治疗期间精囊腺（LAM）中的核酸代谢进行了研究。在成年和青春期前阉割的大鼠中，睾酮治疗使RNA合成有不同程度的增加，且不仅仅取决于精囊腺的肥大程度。在相同条件下，DNA含量以及甲酸-14C掺入DNA的速率呈现出特征性变化：去势后精囊腺萎缩及其随后的恢复似乎伴随着细胞核数量的变化。本文推测了睾酮在DNA复制和细胞有丝分裂中的可能作用；必须通过仔细的形态计量学观察进行进一步研究。
