血清胆红素浓度低是 2 型糖尿病患者发生蛋白尿的一个新的危险因素。
Low serum bilirubin concentration is a novel risk factor for the development of albuminuria in patients with type 2 diabetes.
机构信息
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
出版信息
Metabolism. 2014 Mar;63(3):409-14. doi: 10.1016/j.metabol.2013.11.011. Epub 2013 Nov 20.
OBJECTIVE
Bilirubin has been recognized as an important endogeneous antioxidant. Previous studies reported that bilirubin could prevent atherosclerosis. The aim of this study was to investigate if serum bilirubin concentration could be a predictor for the development of albuminuria in patients with type 2 diabetes.
MATERIALS AND METHODS
We measured serum bilirubin in 320 consecutive patients with normoalbuminuria. We performed follow-up study to assess the development of albuminuria, mean interval of which was 3.2±0.9years. Cox proportional hazards regression was used to examine the relationship between serum bilirubin concentration and the development of albuminuria.
RESULTS
During follow-up duration, 43 patients have developed albuminuria. In multivariate analysis, after adjusting for comprehensive risk factors, the risk of developing albuminuria was higher in the lowest quartile of serum bilirubin concentrations than that in the highest quartile of serum bilirubin concentrations (Hazard ratio, 5.76; 95% CI, 1.65 to 24.93).
CONCLUSIONS
Low serum bilirubin concentration could be a novel risk factor for the development of albuminuria in patients with type 2 diabetes.
目的
胆红素已被认为是一种重要的内源性抗氧化剂。先前的研究表明胆红素可以预防动脉粥样硬化。本研究旨在探讨血清胆红素浓度是否可作为 2 型糖尿病患者白蛋白尿发展的预测因子。
材料和方法
我们测量了 320 例正常白蛋白尿患者的血清胆红素。我们进行了随访研究，以评估白蛋白尿的发展，平均间隔为 3.2±0.9 年。Cox 比例风险回归用于检查血清胆红素浓度与白蛋白尿发展之间的关系。
结果
在随访期间，43 例患者出现了白蛋白尿。在多变量分析中，调整了综合危险因素后，血清胆红素浓度最低四分位数患者发生白蛋白尿的风险高于血清胆红素浓度最高四分位数患者（风险比，5.76；95%CI，1.65 至 24.93）。
结论
低血清胆红素浓度可能是 2 型糖尿病患者白蛋白尿发展的一个新的危险因素。
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