Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
J Diabetes Complications. 2011 Sep-Oct;25(5):309-13. doi: 10.1016/j.jdiacomp.2010.09.004. Epub 2010 Dec 3.
To determine the relationship between serum uric acid, metabolic syndrome (MetS), and albuminuria in type 2 diabetic patients.
A total of 504 Korean patients with type 2 diabetes aged 57.3 years were retrospectively evaluated for clinical histories, anthropometric measurements, and biochemical studies. Urinary albumin excretion (UAE) was measured by a 24-h urine collection.
Prevalence of MetS increased according to the quartiles of uric acid levels (≤3.7, 3.8 to 4.5, 4.6 to 5.5, and >5.5 mg/dl; 52.1%, 52.1%, 57.5%, and 71.6%, respectively, P<.001). Individual components of MetS (abdominal obesity, hypertriglyceridemia, low HDL-cholesterol, high blood pressure) were also significantly associated with the highest quintile of uric acid levels. Serum uric acid levels had significantly increased risk of albuminuria [odds ratio (OR) 1.425, 95% confidence interval (CI) 1.085-1.873] after adjusting for age, gender, and conventional risk factors. Uric acid level remains a significant predictor for abnormal albuminuria after adjusting for MetS presence as well as the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) (OR 1.414, 95% CI 1.071-1.868).
An elevated uric acid level was significantly associated with MetS and was an independent predictor of albuminuria after adjusting for conventional risk factors and MetS. Regular measurements of uric acid level could give information for predicting the presence of MetS and albuminuria in Korean type 2 diabetic patients.
确定血清尿酸、代谢综合征（MetS）与 2 型糖尿病患者白蛋白尿之间的关系。
回顾性评估了 504 名年龄为 57.3 岁的韩国 2 型糖尿病患者的临床病史、人体测量和生化研究。通过 24 小时尿液收集测量尿白蛋白排泄量（UAE）。
根据尿酸水平的四分位数（≤3.7、3.8 至 4.5、4.6 至 5.5 和>5.5 mg/dl；52.1%、52.1%、57.5%和 71.6%，P<.001），MetS 的患病率逐渐增加。MetS 的各个组成部分（腹部肥胖、高三酰甘油血症、低 HDL-胆固醇血症、高血压）也与尿酸水平最高五分位数显著相关。在校正年龄、性别和常规危险因素后，血清尿酸水平与白蛋白尿的发生风险显著相关[比值比（OR）1.425，95%置信区间（CI）1.085-1.873]。在校正 MetS 存在以及血管紧张素转换酶抑制剂（ACEI）或血管紧张素 II 受体阻滞剂（ARB）的使用后，尿酸水平仍然是异常白蛋白尿的显著预测因子（OR 1.414，95%CI 1.071-1.868）。
尿酸水平升高与 MetS 显著相关，在校正常规危险因素和 MetS 后，是白蛋白尿的独立预测因子。定期测量尿酸水平可提供有关预测韩国 2 型糖尿病患者 MetS 和白蛋白尿发生的信息。
