Capoulat M E, Herrera M S, Minsky D M, González S J, Kreiner A J
Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
Gerencia de Investigación y Aplicaciones, CNEA. Av. Gral. Paz 1499, B1650KNA San Martín, Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín. M. de Irigoyen 3100, 1650 San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina.
Appl Radiat Isot. 2014 Jun;88:190-4. doi: 10.1016/j.apradiso.2013.11.037. Epub 2013 Nov 27.
In the frame of accelerator-based BNCT, the (9)Be(d,n)(10)B reaction was investigated as a possible source of epithermal neutrons. In order to determine the configuration in terms of bombarding energy, target thickness and Beam Shaping Assembly (BSA) design that results in the best possible beam quality, a systematic optimization study was carried out. From this study, the optimal configuration resulted in tumor doses ≥40Gy-Eq, with a maximum value of 51Gy-Eq at a depth of about 2.7cm, in a 60min treatment. The optimal configuration was considered for the treatment planning assessment of a real Glioblastoma Multiforme case. From this, the resulted dose performances were comparable to those obtained with an optimized (7)Li(p,n)-based neutron source, under identical conditions and subjected to the same clinical protocol.
在基于加速器的硼中子俘获疗法（BNCT）框架下，研究了（9）Be（d，n）（10）B反应作为超热中子可能来源的情况。为了确定在轰击能量、靶厚度和束流整形组件（BSA）设计方面能产生最佳束流质量的配置，开展了一项系统优化研究。通过该研究，在60分钟的治疗中，最佳配置产生的肿瘤剂量≥40Gy-Eq，在约2.7厘米深度处的最大值为51Gy-Eq。针对一例真实的多形性胶质母细胞瘤病例的治疗计划评估考虑了最佳配置。由此得出的剂量性能与在相同条件下并遵循相同临床方案使用优化的基于（7）Li（p，n）的中子源所获得的剂量性能相当。
