初诊 IgA 肾病患者中 CD4⁺CXCR5⁺T 滤泡辅助细胞频率较高。
A higher frequency of CD4⁺CXCR5⁺ T follicular helper cells in patients with newly diagnosed IgA nephropathy.
机构信息
Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China; Department of Nephrology, the First Hospital of Jilin University, Changchun 130021, China.
Key Laboratory of Zoonosis Research, Ministry of Education, the First Hospital of Jilin University, Changchun 130032, China.
出版信息
Immunol Lett. 2014 Mar-Apr;158(1-2):101-8. doi: 10.1016/j.imlet.2013.12.004. Epub 2013 Dec 12.
The frequency of different subsets of CD4(+)CXCR5(+) TFH cells and the levels of serum cytokines were examined in 24 patients with newly diagnosed IgAN before and 8-12 weeks after treatment and in 12 healthy controls (HC). In comparison with HC, significantly higher percentages of CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+), CD4(+)CXCR5(+)PD-1(+) TFH cells and higher levels of serum IL-17A, IFN-γ, IL-2, IL-10, IL-4 and IL-21 were detected in IgAN patients. The percentages of CD4(+)CXCR5(+) TFH cells were negatively correlated with the values of eGFR and CD4(+)CXCR5(+)PD-1(+) TFH cells were correlated positively with the levels of serum IL-21 and Gd-IgA1 as well as 24h urinary proteins. Treatment with prednisone significantly reduced the frequency of CD4(+)CXCR5(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells and the levels of serum IL-21, but increased IL-4 and IL-10 in those patients. A higher frequency of CD4(+)CXCR5(+) TFH cells existed in patients with IgAN and may be associated with the development of IgAN.
研究人员在 24 例新诊断的 IgAN 患者治疗前和治疗后 8-12 周以及 12 例健康对照者（HC）中，检测了不同亚群的 CD4(+)CXCR5(+)TFH 细胞频率和血清细胞因子水平。与 HC 相比，IgAN 患者的 CD4(+)CXCR5(+)、CD4(+)CXCR5(+)ICOS(+)、CD4(+)CXCR5(+)PD-1(+)TFH 细胞比例显著升高，血清 IL-17A、IFN-γ、IL-2、IL-10、IL-4 和 IL-21 水平也升高。CD4(+)CXCR5(+)TFH 细胞比例与 eGFR 值呈负相关，CD4(+)CXCR5(+)PD-1(+)TFH 细胞与血清 IL-21、Gd-IgA1 和 24 小时尿蛋白水平呈正相关。泼尼松治疗显著降低了 CD4(+)CXCR5(+)和 CD4(+)CXCR5(+)PD-1(+)TFH 细胞的频率，以及血清 IL-21 水平，但增加了 IL-4 和 IL-10。IgAN 患者中 CD4(+)CXCR5(+)TFH 细胞的频率较高，可能与 IgAN 的发生有关。
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