Boraschi Diana, Penton-Rol Giselle
National Research Council, Institute of Protein Biochemistry, Napoli, Italy.
Center for Genetic Engineering and Biotechnology, Havana City, Cuba.
Immunol Lett. 2014 Oct;161(2):211-5. doi: 10.1016/j.imlet.2013.11.017. Epub 2013 Dec 12.
Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in a wide variety of diseases, from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumors, chronic inflammatory and degenerative diseases, metabolic disorders, etc.). This brief review will summarize some of the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression, by considering the following aspects:
鉴于异常免疫在多种疾病中发挥核心作用，从最典型的免疫相关综合征（自身免疫性疾病、过敏和哮喘、免疫缺陷）到那些免疫和炎症改变决定病理结果的疾病（慢性感染、肿瘤、慢性炎症和退行性疾病、代谢紊乱等），为治疗目的调节免疫反应是一个特别相关的领域。本简要综述将通过考虑以下方面，总结免疫药理学的一些最有前景的观点，特别是在免疫抑制领域：
