Zhang Yuan-Yuan, Shao Meng-Yu, Yu Xiao-Hui, Zhao Jing, Zhang Guo-Zhong
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
Infect Genet Evol. 2014 Jan;21:359-66. doi: 10.1016/j.meegid.2013.12.003. Epub 2013 Dec 11.
Newcastle disease (ND) is one of the most important diseases of poultry, and causes severe economic losses in the global poultry industry. Although all Newcastle disease virus (NDV) isolates belong to a single serotype, significant genetic diversity has been described between different NDV isolates. Here, we report the molecular characterization of 23 virulent genotype VIId NDV isolates of class II circulating in China. Phylogenetic construction and analysis revealed the existence of distinctly genomic and amino acid differences that clearly distinguished these isolates from other typical NDV genotypes and vaccine strains. We also report a new 582-amino-acid hemagglutinin-neuraminidase in genotype VII NDV strains. This is believed to be the first study to investigate systematically the most predominant NDV strains, and provides more information on the genetic nature of genotype VIId NDV of class II circulating in China.
新城疫（ND）是家禽最重要的疾病之一，在全球家禽业造成严重经济损失。尽管所有新城疫病毒（NDV）分离株都属于单一血清型，但不同NDV分离株之间已被描述存在显著的遗传多样性。在此，我们报告了在中国流行的23株II类强毒基因型VII d NDV分离株的分子特征。系统发育构建和分析揭示了明显的基因组和氨基酸差异的存在，这些差异将这些分离株与其他典型NDV基因型和疫苗株清楚地区分开来。我们还报告了基因型VII NDV毒株中一种新的582个氨基酸的血凝素神经氨酸酶。据信这是首次对最主要的NDV毒株进行系统研究，并提供了关于在中国流行的II类基因型VII d NDV遗传特性的更多信息。
