体内非靶向辐射效应：放射生物学未来的批判性展望。
Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology.
机构信息
Radiation Protection Laboratory, Health Physics, Radiobiology and Cytogenetics, Institute of Nuclear & Radiological Science & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", 15310 Aghia Paraskevi, Athens, Greece.
Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou 15780, Athens, Greece.
出版信息
Cancer Lett. 2015 Jan 1;356(1):34-42. doi: 10.1016/j.canlet.2013.11.018. Epub 2013 Dec 13.
Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.
辐射诱导的旁观者效应（RIBE）表明，在未直接受到辐射或电离事件产生的自由基照射的细胞中诱导出生物非靶向效应。尽管已经使用各种生物学终点证明了 RIBE 的存在，但这种现象的机制仍不清楚。本文讨论了体外 RIBE 的有争议结果以及各种体内系统中非靶向效应的证据。RIBE 的实验证据表明，需要更深入的分析和机制方法来回答放射生物学中最引人关注的问题之一。
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