Narita Kosuke, Noro Rintaro, Seike Masahiro, Matsumoto Masaru, Fujita Kazue, Matsumura Jiro, Takahashi Mikiko, Kawamoto Masashi, Gemma Akihiko
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan.
Intern Med. 2013;52(24):2805-9. doi: 10.2169/internalmedicine.52.0523.
Histiocytic sarcoma (HS) is a rare malignancy of soft tissues with an unknown etiology. The CHOP (cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride and prednisolone) regimen is often adopted as first-line chemotherapy; however, its therapeutic efficacy against HS is usually low. We herein first present the case of a patient with HS who was infected with human immunodeficiency virus-1 (HIV) in whom treatment with a combination of CHOP and antiretroviral therapy (ART) was successful. The patient has been in complete remission for 12 months following the discontinuation of chemotherapy under continuous ART. This case report may help to promote further investigation of both HS and HIV-related malignancy.
组织细胞肉瘤（HS）是一种病因不明的罕见软组织恶性肿瘤。CHOP（环磷酰胺、硫酸长春新碱、盐酸多柔比星和泼尼松龙）方案常被用作一线化疗；然而，其对HS的治疗效果通常较低。我们在此首次报告一例感染人类免疫缺陷病毒1型（HIV）的HS患者，该患者采用CHOP与抗逆转录病毒疗法（ART）联合治疗取得成功。在持续ART治疗下停止化疗后，该患者已完全缓解12个月。本病例报告可能有助于推动对HS和HIV相关恶性肿瘤的进一步研究。
