PAX2和PAX8：转移性积液的有用标志物。

PAX2 and PAX8: useful markers for metastatic effusions.

作者信息

Waters Lindsay, Crumley Suzanne, Truong Luan, Mody Dina, Coffey Donna

机构信息

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Tex., USA.

出版信息

Acta Cytol. 2014;58(1):60-6. doi: 10.1159/000356426. Epub 2013 Dec 7.

DOI:10.1159/000356426

PMID:24334997

Abstract

OBJECTIVE

It was the aim of this study to determine the utility of PAX2 and PAX8 in cytology effusions with metastatic tumor.

STUDY DESIGN

PAX2 and PAX8 immunohistochemical staining was performed on cell blocks of 89 pleural, pericardial and peritoneal effusions with benign diagnoses (18 cases), or secondary to renal cell carcinoma (RCC; 9 cases), müllerian carcinoma (21 cases) or non-müllerian carcinoma (41 cases).

RESULTS

PAX2 stained 0% (0/18) of controls, 100% (8/8) of RCCs, 35% (7/20) of müllerian carcinomas, and 2% (1/41) of non-müllerian carcinomas. PAX8 stained 6% (1/18) of control cases, 100% (9/9) of RCC cases, 100% (20/20) of müllerian carcinomas, and 5% (2/41) of non-müllerian carcinomas. PAX2 was 35% sensitive and 95% specific for müllerian carcinoma and 100% sensitive and 95% specific for RCC. PAX8 was 100% sensitive and 95% specific for müllerian carcinoma and 100% sensitive and 95% specific for RCC.

CONCLUSIONS

PAX8 is more sensitive than PAX2 for metastatic effusions from müllerian carcinomas (100 vs. 35%), while also having a higher intensity of staining than PAX2. However, PAX2 and PAX8 are both highly sensitive and specific for RCCs. PAX2 and PAX8 are valuable diagnostic markers for metastatic müllerian carcinomas and RCCs in effusion cytology. PAX8 is superior for carcinomas of müllerian origin.

摘要

目的

本研究旨在确定PAX2和PAX8在伴有转移性肿瘤的细胞学积液中的应用价值。

研究设计

对89例胸膜、心包和腹膜积液的细胞块进行PAX2和PAX8免疫组化染色，这些积液的诊断为良性（18例），或继发于肾细胞癌（RCC；9例）、苗勒管癌（21例）或非苗勒管癌（41例）。

结果

PAX2在对照组中的染色阳性率为0%（0/18），在RCC中的染色阳性率为100%（8/8），在苗勒管癌中的染色阳性率为35%（7/20），在非苗勒管癌中的染色阳性率为2%（1/41）。PAX8在对照病例中的染色阳性率为6%（1/18），在RCC病例中的染色阳性率为100%（9/9），在苗勒管癌中的染色阳性率为100%（20/20），在非苗勒管癌中的染色阳性率为5%（2/41）。PAX2对苗勒管癌的敏感性为35%，特异性为95%，对RCC的敏感性为100%，特异性为95%。PAX8对苗勒管癌的敏感性为100%，特异性为95%，对RCC的敏感性为100%，特异性为95%。