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[大鼠感觉神经元本体发育过程中体膜电兴奋性离子机制的变化。内向电流离子通道的分布]

[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Distribution of ion channels of the inward current].

作者信息

Kostiuk P G, Fedulova S A, Veselovskiĭ N S

出版信息

Neirofiziologiia. 1986;18(6):813-20.

PMID:2433609
Abstract

Distribution of different types of ionic channels carrying inward currents was studied in the somatic membrane of rat dorsal root ganglion neurons within three age groups: 5-9 days, 45 days and 90 postnatally. The number of neurons whose membrane contained simultaneously four types of inward current channels ("fast" tetrodotoxin-sensitive and "slow" tetrodotoxin-resistant sodium low- and high-threshold calcium one's) was progressively reduced in successive groups. The first group contained 14.5%, the second 5% and the third group 1% of such neurons. These changes were due to disappearance of "slow" sodium and low-threshold calcium channels from the membrane; the number of neurons whose somatic membrane contained only two types of inward current channels ("fast" sodium and high-threshold calcium) has increased, respectively.

摘要

在三个年龄组(出生后5 - 9天、45天和90天)的大鼠背根神经节神经元的体膜中,研究了携带内向电流的不同类型离子通道的分布情况。膜中同时包含四种内向电流通道(“快速”河豚毒素敏感型和“慢速”河豚毒素抗性型钠通道以及低阈值和高阈值钙通道)的神经元数量在连续的组中逐渐减少。第一组中这类神经元占14.5%,第二组占5%,第三组占1%。这些变化是由于膜中“慢速”钠通道和低阈值钙通道消失所致;其体膜仅包含两种内向电流通道(“快速”钠通道和高阈值钙通道)的神经元数量相应增加。

相似文献

1
[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Distribution of ion channels of the inward current].[大鼠感觉神经元本体发育过程中体膜电兴奋性离子机制的变化。内向电流离子通道的分布]
Neirofiziologiia. 1986;18(6):813-20.
2
[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Density ratios of inward currents].[大鼠感觉神经元躯体膜电兴奋性离子机制在个体发育过程中的变化。内向电流密度比]
Neirofiziologiia. 1986;18(6):820-7.
3
[Changes in the ionic mechanisms of the electro-excitability of the somatic membrane of rat sensory neurons during ontogenesis. Relation between calcium channels and intracellular metabolism].[大鼠感觉神经元躯体膜电兴奋性离子机制在个体发育过程中的变化。钙通道与细胞内代谢的关系]
Neirofiziologiia. 1986;18(6):827-32.
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[Variations in the ionic currents as dependent on the size of the sensory neurons in newborn rats].
Fiziol Zh (1994). 1999;45(4):41-7.
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[The potential dependence of calcium current deactivation via the somatic membrane of sensory neurons in the mouse].[小鼠感觉神经元胞体膜钙电流失活的潜在依赖性]
Neirofiziologiia. 1988;20(2):185-93.
6
Ionic mechanisms of electrical excitability in rat sensory neurons during postnatal ontogenesis.大鼠感觉神经元出生后个体发育过程中电兴奋性的离子机制
Neuroscience. 1991;41(1):303-9. doi: 10.1016/0306-4522(91)90219-e.
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Effect of pH on fast sodium channels in neurons of the rat dorsal root ganglion.pH对大鼠背根神经节神经元快速钠通道的影响。
Gen Physiol Biophys. 1985 Aug;4(4):359-65.
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[Single channels of low and high-threshold calcium channels of the membrane of sensory neurons in the mouse].[小鼠感觉神经元膜上低阈值和高阈值钙通道的单通道研究]
Neirofiziologiia. 1986;18(3):412-6.
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[Effect of replacing calcium ions with barium ions in studies of the inward currents of mammalian neurons].[在哺乳动物神经元内向电流研究中用钡离子替代钙离子的效果]
Neirofiziologiia. 1986;18(3):313-8.
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[Deactivation of calcium currents in the soma of spinal ganglion neurons after elimination of the depolarizing shift in the membrane potential].
Neirofiziologiia. 1985;17(5):682-91.

引用本文的文献

1
The minimal provision principle of functional systems. Neuronal mechanisms.功能系统的最小供给原则。神经元机制。
Neurosci Behav Physiol. 2000 Nov-Dec;30(6):653-69. doi: 10.1023/a:1026646716069.
2
Three types of calcium channels in the membrane of mouse sensory neurons.小鼠感觉神经元膜中的三种钙通道。
Pflugers Arch. 1988 Jun;411(6):661-9. doi: 10.1007/BF00580863.