Bell K, Pfeiffer N, Grus F H
Augenklinik, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland,
Ophthalmologe. 2014 Feb;111(2):107-12. doi: 10.1007/s00347-013-2931-x.
The pharmacokinetics of the anterior eye comprises the application, resorption, bioavailability, metabolization and elimination of topically administered drugs. In addition to the necessity of the penetration of the substance through the naturally occurring barriers of the eye in the form of the tear film, cornea, conjunctiva and sclera, the correct technique for administration is necessary for an optimal effect of the drug. Several new application devices have been described in the literature but most are still in an experimental phase. The main aims are to increase drug exposure time to the anterior surface of the eye and decrease problems in administration. Furthermore, new preservative agents are in use in order to produce less toxic side effects.
眼前段的药代动力学包括局部给药药物的应用、吸收、生物利用度、代谢和消除。除了药物必须以泪膜、角膜、结膜和巩膜的形式穿透眼睛的天然屏障外，正确的给药技术对于药物的最佳效果也是必要的。文献中描述了几种新的给药装置，但大多数仍处于实验阶段。主要目的是增加药物在眼前表面的暴露时间并减少给药问题。此外，正在使用新的防腐剂以产生毒性较小的副作用。
