表没食子儿茶素-3-没食子酸酯可诱导胶质瘤细胞凋亡、抑制其增殖并降低其侵袭能力。
Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell.
作者信息
Li Hong, Li Zhe, Xu Ya-Ming, Wu Yue, Yu Kang-Kang, Zhang Can, Ji Yong-Hua, Ding Gang, Chen Fu-Xue
机构信息
School of Life Sciences, Shanghai University, Shanghai, 200444, China.
出版信息
Neurosci Bull. 2014 Feb;30(1):67-73. doi: 10.1007/s12264-013-1394-z. Epub 2013 Dec 13.
Abstract
Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67 kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention.
摘要
表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中的一种主要多酚类物质，被认为是一种潜在的癌症治疗和化学预防剂。胶质瘤是一种死亡率很高的恶性肿瘤，但尚未开发出有效的治疗方法。在本研究中，我们发现EGCG通过层粘连蛋白受体（分子量67 kDa）以时间和剂量依赖性方式诱导U251胶质瘤细胞凋亡，降低其侵袭性并抑制其增殖。丝裂原活化蛋白激酶途径被证明参与胶质瘤细胞的凋亡和增殖。此外，EGCG处理后基质金属蛋白酶（MMP）-2和MMP-9的mRNA水平降低。这些结果表明，EGCG具有重要的治疗作用，且毒性和副作用较低，可用于癌症化学预防。
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Biochem Biophys Res Commun. 2013 Aug 23;438(2):370-4. doi: 10.1016/j.bbrc.2013.07.078. Epub 2013 Jul 26.
2
3
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4
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Neurosci Lett. 2008 Dec 19;448(1):161-5. doi: 10.1016/j.neulet.2008.10.036. Epub 2008 Oct 17.
5
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6
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7
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