Bomirski A, Słomiński A
Acta Derm Venereol. 1986;66(6):520-3.
When the hamster Ab amelanotic melanoma has been grown as subcutaneous transplants in hamsters, melanin and identifiable melanosomes have never been observed by electron microscopy. When the cells were placed in primary cell culture, melanosomes of a granular type which contained small amounts of melanin appeared during the first 24 hours of cell culture. As the cultures grew older, the number and degree of melanization of the melanosomes increased, and eventually after 3-5 days they were found in all melanoma cells.
当将仓鼠无黑色素黑色素瘤作为皮下移植瘤在仓鼠体内生长时，通过电子显微镜从未观察到黑色素和可识别的黑素小体。当将这些细胞进行原代细胞培养时，在细胞培养的最初24小时内出现了含有少量黑色素的颗粒型黑素小体。随着培养时间延长，黑素小体的数量和黑色素化程度增加，最终在3 - 5天后在所有黑色素瘤细胞中都能发现它们。
