Lavrijsen A P, Van Dijke C, Vermeer B J
Acta Derm Venereol. 1986;66(6):536-8.
We present a patient with psoriasis who developed exfoliative dermatitis with concomitant fever, malaise and liver enzyme elevations, two days after the introduction of the new calcium antagonist diltiazem. The symptoms rapidly resolved after discontinuation of diltiazem and treatment with prednisone. Three years previously, this patient developed a similar reaction after 12 days of treatment with chloroquine. Diltiazem and chloroquine have a structural resemblance, which suggests that cross-reactions between these drugs may occur.
我们报告一名银屑病患者，在开始使用新型钙拮抗剂地尔硫䓬两天后，出现了剥脱性皮炎，并伴有发热、不适和肝酶升高。停用 地尔硫䓬并使用泼尼松治疗后，症状迅速缓解。三年前，该患者在使用氯喹治疗 12 天后出现了类似反应。地尔硫䓬和氯喹在结构上有相似之处，这表明这些药物之间可能会发生交叉反应。
