Josephson M A, Singh B N
Angiology. 1986 Dec;37(12 Pt 2):950-8.
The hemodynamic effects of the class III antiarrhythmic agent N-acetylprocainamide or NAPA were assessed in 14 patients with preserved ventricular function undergoing cardiac catheterization. Intravenous NAPA is a relatively weak peripheral arterial and venous dilator which reduces cardiac output producing a reflex increase in the heart rate. The hemodynamic profile of NAPA is compared to and contrasted with other antiarrhythmic drugs, many of which exert significant depressant effects on left ventricular function. The hemodynamic profile of NAPA is favorable for an antiarrhythmic agent but further data are necessary to define its effects in patients with severely depressed myocardial performance.
对14例心功能正常且正在接受心导管检查的患者评估了Ⅲ类抗心律失常药物N - 乙酰普鲁卡因胺（NAPA）的血流动力学效应。静脉注射NAPA是一种相对较弱的外周动脉和静脉扩张剂，它会降低心输出量，从而引起心率反射性增加。将NAPA的血流动力学特征与其他抗心律失常药物进行了比较和对比，其中许多药物对左心室功能有显著的抑制作用。NAPA的血流动力学特征对于一种抗心律失常药物来说是有利的，但需要更多数据来确定其对心肌功能严重受损患者的影响。
