免疫化学粪便检测（FIT）在无症状人群结直肠癌筛查中检测进展性腺瘤的有效性。

Effectiveness of the immunochemical fecal test (FIT) for detection of advanced adenomas in colorectal carcinoma screening in an asymptomatic population.

作者信息

Miuţescu B, Sporea I, Popescu Alina, Bota Simona, Iovănescu Dana, Burlea Amelia, Mos Liana, Palaghia Mădălina, Vasilescu A, Miuţescu E

机构信息

University of Medicine and Pharmacy "Victor Babel" - Timişoara.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2013 Apr-Jun;117(2):302-7.

PMID:24340508

Abstract

AIM

The aim of the study was to evaluate the benefit of the immunochemical fecal blood test (FIT) for detection of advanced adenomas.

MATERIAL AND METHODS

We have conducted a screening study on a average-risk cohort of subjects, aged 50 -74 years. We used a rapid quantitative FIT to perform the screening. Colonoscopy was recommended in all participants with positive FIT. We assessed the participation rate and analyzed advanced adenomas detected in the screening examinations.

RESULTS

Our study enrolled 1111 asymptomatic participants. Immunochemical test results were positive in 72 subjects (6.5%). Colonoscopy was performed by 50/72 (69.4%) subjects. The detection rate for advanced adenomas was 2.2%. A total number of 28 advanced adenomas were detected in 24 subjects, meaning 1.2 advanced adenoma/subject. Analyzing the 3 characteristics of advanced adenomas, we observed in our study that 25/28 adenomas (89.3%) had sizes > or = 10 mm, 11/28 adenomas (39.3%) were tubulovillous/villous and 19/28 adenomas (67.9%) had high dysplasia. The majority of advanced adenomas were found in the left colon as compared to the right colon: 71.4% vs. 28.6%. p = 0.0008.

CONCLUSIONS

In our study was obtained a 2.2% detection rate for advanced adenomas, most of them (71.4%) being located in the left colon. The dominant feature of advanced adenomas detected was the size > or = 10 mm (89.3% of cases).

摘要

目的

本研究旨在评估免疫化学粪便潜血试验（FIT）对检测进展性腺瘤的益处。

材料与方法

我们对年龄在50 - 74岁的平均风险队列受试者进行了一项筛查研究。我们使用快速定量FIT进行筛查。所有FIT呈阳性的参与者均被建议进行结肠镜检查。我们评估了参与率，并分析了筛查检查中检测到的进展性腺瘤。

结果

我们的研究招募了1111名无症状参与者。免疫化学检测结果在72名受试者中呈阳性（6.5%）。50/72（69.4%）名受试者接受了结肠镜检查。进展性腺瘤的检出率为2.2%。在24名受试者中共检测到28个进展性腺瘤，即每位受试者1.2个进展性腺瘤。分析进展性腺瘤的三个特征，我们在研究中观察到25/28个腺瘤（89.3%）的大小≥10 mm，11/28个腺瘤（39.3%）为管状绒毛状/绒毛状，19/28个腺瘤（67.9%）有高度不典型增生。与右半结肠相比，大多数进展性腺瘤位于左半结肠：71.4% 对 28.6%，p = 0.0008。