Iarustovskiĭ M B, Samsonova N N, Rogal'skaia E A, Klimovich L G, Pliushch M G, Abramian M V, Krotenko N P, Niiazmatov A A
Anesteziol Reanimatol. 2013 May-Jun(3):25-9.
Medical technologies development and recent approaches in management of patients with septic complications during the early postoperative period present new obstacles to the laboratory service. Endotoxin is a main agent in the systemic inflammatory cascade and plays important role in sepsis pathogenesis. Recent express methods of diagnostics allow determining blood activity of endotoxin during 30-50 min. 55 ICU patients with clinical and laboratory signs of systemic inflammatory response syndrome (SIRS) after cardiac surgery were studied in the single-center prospective research. Endotoxaemia was diagnosed by express tests. Level of endotoxaemia was assessed before and after sorption in 15 patients receiving complex intensive care with selective lipopolysaccharide (LPS) adsorption. Endotoxaemia level assessment allows to define indications for different programs of intensive care in time and to assess its efficiency. Test systems for assessment endotoxin level based on the principle of interaction antigen - antibody (EAA and MACH-endotox spp.) is a most efficient for express diagnostics of endotoxaemia.
医疗技术的发展以及术后早期脓毒症并发症患者管理的最新方法给实验室服务带来了新的障碍。内毒素是全身炎症级联反应中的主要介质，在脓毒症发病机制中起重要作用。最近的快速诊断方法能够在30 - 50分钟内测定血液中的内毒素活性。在一项单中心前瞻性研究中，对55例心脏手术后出现全身炎症反应综合征（SIRS）临床和实验室体征的重症监护病房（ICU）患者进行了研究。通过快速检测诊断内毒素血症。对15例接受选择性脂多糖（LPS）吸附综合重症监护的患者，在吸附前后对内毒素血症水平进行了评估。内毒素血症水平评估有助于及时确定不同重症监护方案的适应症并评估其疗效。基于抗原 - 抗体相互作用原理的内毒素水平评估测试系统（EAA和MACH - endot spp.）对于内毒素血症的快速诊断最为有效。
