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无法治愈的癌症和胃肠道梗阻患者的发病率和死亡率以外的结局指标。

Outcome measures other than morbidity and mortality for patients with incurable cancer and gastrointestinal obstruction.

作者信息

Badgwell Brian, Krouse Robert, Klimberg Suzanne V, Bruera Eduardo

机构信息

1 Department of Surgery, The University of Arkansas for Medical Sciences , Little Rock, Arkansas.

出版信息

J Palliat Med. 2014 Jan;17(1):18-26. doi: 10.1089/jpm.2013.0240. Epub 2013 Dec 17.

Abstract

OBJECTIVE

To prospectively evaluate outcome measures of patients undergoing palliative surgical evaluation for gastrointestinal obstruction.

METHODS

Patients with an incurable malignancy undergoing consultation for gastrointestinal obstruction were prospectively enrolled from November 2009 to July 2012. We evaluated two patient-reported outcome measures of quality of life (Functional Assessment of Cancer Therapy-General [FACT-G]) and treatment satisfaction (Functional Assessment of Chronic Illness Therapy-Treatment Satisfaction-General Version 1 [FACIT-TS-G]) and five observational outcome measures (symptom improvement, 30 "good days," ability to tolerate diet at discharge, discharge home, and death within 90 days).

RESULTS

Of 53 patients enrolled, 13 had gastric outlet obstruction, 22 had small bowel obstruction, and 18 had large bowel obstruction. Patient-reported measures could not be analyzed because only 19 patients (36%) completed the FACT-G and FACIT-TS-G survey at 1-month follow-up. However, we were able to obtain results for the 5 clinical observational outcomes in all patients. Symptom improvement was obtained in 41 (77%) patients, 30 "good days" in 40 (75%), ability to tolerate diet at discharge in 45 (85%), discharge to home in 46 (87%), and 18 (34%) of patients died within 90 days of evaluation. Large bowel obstruction was associated with symptom improvement, and noncolorectal cancer histology and carcinomatosis were negatively associated with having 30 "good days." The ability to tolerate oral intake at discharge was associated with Eastern Cooperative Oncology Group performance status and no recent chemotherapy administration. Death within 90 days was independently associated with noncolorectal cancer histology, ascites, and nonsurgical treatment.

CONCLUSIONS

Observational outcome measures can provide follow-up data and the identification of variables associated with outcome for patients who are unable to respond to outpatient surveys.

摘要

目的

前瞻性评估接受姑息性手术评估以治疗胃肠道梗阻的患者的结局指标。

方法

2009年11月至2012年7月前瞻性纳入因胃肠道梗阻接受会诊的无法治愈的恶性肿瘤患者。我们评估了两项患者报告的生活质量结局指标(癌症治疗功能评估通用版 [FACT-G])和治疗满意度指标(慢性病治疗功能评估-治疗满意度通用版1 [FACIT-TS-G])以及五项观察性结局指标(症状改善、30个“好日子”、出院时耐受饮食的能力、出院回家以及90天内死亡)。

结果

在纳入的53例患者中,13例有胃出口梗阻,22例有小肠梗阻,18例有大肠梗阻。由于只有19例患者(36%)在1个月随访时完成了FACT-G和FACIT-TS-G调查,因此无法对患者报告的指标进行分析。然而,我们能够获得所有患者的5项临床观察性结局的结果。41例(77%)患者症状得到改善,40例(75%)有30个“好日子”,45例(85%)患者出院时能够耐受饮食,46例(87%)患者出院回家,18例(34%)患者在评估后90天内死亡。大肠梗阻与症状改善相关,非结直肠癌组织学类型和癌性腹膜炎与有30个“好日子”呈负相关。出院时耐受口服摄入的能力与东部肿瘤协作组体能状态以及近期未进行化疗有关。90天内死亡独立与非结直肠癌组织学类型、腹水和非手术治疗相关。

结论

观察性结局指标可为无法回应门诊调查的患者提供随访数据并识别与结局相关的变量。

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