Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnapdong Songpagu, Seoul, 138-736, Korea.
Br J Dermatol. 2014 May;170(5):1173-6. doi: 10.1111/bjd.12755.
Although more than 300 cases of eosinophilic pustular folliculitis (EPF) have been reported to date, differences in clinicohistopathological findings among affected sites have not yet been evaluated.
To evaluate differences in the clinical and histopathological features of facial and extrafacial EPF.
Forty-six patients diagnosed with EPF were classified into those with facial and extrafacial disease according to the affected site. Clinical and histopathological characteristics were retrospectively compared, using all data available in the patient medical records.
There were no significant between-group differences in subject ages at presentation, but a male predominance was observed in the extrafacial group. In addition, immunosuppression-associated type EPF was more common in the extrafacial group. Eruptions of plaques with an annular appearance were more common in the facial group. Histologically, perifollicular infiltration of eosinophils occurred more frequently in the facial group, whereas perivascular patterns occurred more frequently in the extrafacial group. Follicular mucinosis and exocytosis of inflammatory cells in the hair follicles were strongly associated with facial EPF.
The clinical and histopathological characteristics of patients with facial and extrafacial EPF differ, suggesting the involvement of different pathogenic processes in the development of EPF at different sites.
尽管迄今为止已有超过 300 例嗜酸性脓疱性毛囊炎 (EPF) 被报道，但受累部位的临床组织病理学表现差异尚未得到评估。
评估面部和非面部 EPF 的临床和组织病理学特征差异。
根据受累部位将 46 例诊断为 EPF 的患者分为面部和非面部疾病组。回顾性比较了患者病历中所有可用数据的临床和组织病理学特征。
两组患者的发病年龄无显著差异，但非面部组男性居多。此外，非面部组更常出现与免疫抑制相关的 EPF 类型。面部组的斑块状皮损更常见呈环状外观。组织学上，面部组更常出现毛囊周围嗜酸性粒细胞浸润，而非面部组更常出现血管周围模式。毛囊内粘蛋白沉积和炎症细胞外溢与面部 EPF 密切相关。
面部和非面部 EPF 患者的临床和组织病理学特征不同，提示 EPF 在不同部位的发病过程中涉及不同的发病机制。
