Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center, Johannes-Gutenberg University, Mainz, Germany.
Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center, Johannes-Gutenberg University, Mainz, Germany.
J Vasc Surg. 2014 Mar;59(3):675-83. doi: 10.1016/j.jvs.2013.09.029. Epub 2013 Dec 15.
To analyze early and late mortality, venous morbidity, reinfection, and freedom from reintervention after using the femoral vein (FV) for vascular reconstruction with infection of the aortoiliofemoral axis.
By reviewing our database, 86 patients could be identified with implantation of FV grafts in infected fields between November 1995 and July 2012. The patient records were retrospectively analyzed and follow-up information obtained from patients or their general physician. Seventy-one patients presented with prosthetic graft infection and 15 with an infected aneurysm. For data analysis, patients were divided into an aortoiliac (n = 67) and a femoral group (n = 19). Study end points assessed were early and late mortality, incidence of deep vein thrombosis of the FV donor limb, graft patency, limb salvage, reinfection, and freedom from reintervention.
Sixty-seven aortoiliac reconstructions were performed using 84 FV grafts with an operative mortality of 9%. After a mean follow-up of 45 months, survival, patency, limb salvage, and freedom from reintervention were 45%, 97%, 94%, and 91%, respectively, at 5 years. Twenty FV grafts were employed for 19 femoral reconstructions with an operative mortality of 10.5%. Here, mean follow-up was 35 months and survival, patency, limb salvage, and freedom from reintervention were 29%, 87%, 93%, and 81%, respectively, at 5 years. Specimen culture confirmed Staphylococcus (epidermidis and aureus) as the predominant microorganism. Venous morbidity after FV harvest showed an incidence of deep venous thrombosis of 13.7% for popliteal and 10.6% for tibial level at a follow-up of 24 months with only mild clinical symptoms (21% limb swelling).
Vascular reconstruction using autologous FV in arterial and graft infection of the aortoiliofemoral axis provides durable long-term results with acceptable mortality and morbidity.
分析使用股静脉(FV)进行血管重建后,在主髂股动脉感染部位发生的早期和晚期死亡率、静脉发病率、再感染以及免于再次干预的情况。
通过回顾我们的数据库,1995 年 11 月至 2012 年 7 月期间,我们确定了 86 例在感染区域植入 FV 移植物的患者。对患者的病历进行回顾性分析,并从患者或其全科医生处获得随访信息。71 例患者出现人工移植物感染,15 例患者出现感染性动脉瘤。为了进行数据分析,患者分为主髂组(n = 67)和股组(n = 19)。评估的研究终点包括早期和晚期死亡率、FV 供肢深静脉血栓形成的发生率、移植物通畅率、肢体存活率、再感染和免于再次干预的情况。
67 例主髂重建术采用 84 根 FV 移植物,手术死亡率为 9%。平均随访 45 个月后,5 年时的生存率、通畅率、肢体存活率和免于再次干预的比例分别为 45%、97%、94%和 91%。19 例股重建术采用 20 根 FV 移植物,手术死亡率为 10.5%。这里,平均随访时间为 35 个月,5 年时的生存率、通畅率、肢体存活率和免于再次干预的比例分别为 29%、87%、93%和 81%。标本培养证实金黄色葡萄球菌(表皮葡萄球菌和金黄色葡萄球菌)是主要的微生物。FV 采集后静脉发病率为:随访 24 个月时,腘静脉和胫静脉深静脉血栓形成的发生率分别为 13.7%和 10.6%,仅有轻微的临床症状(21%的肢体肿胀)。
在主髂股动脉的动脉和移植物感染中使用自体 FV 进行血管重建,可提供持久的长期结果,死亡率和发病率可接受。