First Geriatric Cardiology Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
First Geriatric Cardiology Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email:
Chin Med J (Engl). 2013;126(24):4608-11.
Growing epidemiologic evidence has indicated that genetics can predispose individuals to the occurrence of lone atrial fibrillation (AF). The angiotensin-converting enzyme 2 (ACE2) gene has been established to be associated with hypertension and left ventricular hypertrophy. The objective of our study was to investigate the association of ACE2 gene polymorphisms with lone AF.
A total of 265 consecutive lone AF patients and 289 healthy controls were successfully investigated. The polymorphisms rs2106809 and rs2285666 were genotyped by polymerase chain reaction (PCR) and direct sequencing. A Logistic regression model was used to determine the odds ratio (OR) and 95% confidence intervals (CI) of variations of ACE2 for lone AF.
The T allele of rs2106809 conferred an increased risk for lone AF (OR 1.24, 95% CI 1.01-1.52, P = 0.03) in males after adjustment for conventional risk factors. SNP at rs2285666 in males was not significantly different between AF patients and controls. No association was found between the two polymorphisms in the female population with lone AF. After (36.3 ± 4.5) months of follow-up, the end point data were obtained: death (cardiac and noncardiac), ischemic stroke, and heart failure. In the male subgroup, the associations between rs2106809 T male carriers and combined end points including ischemic stroke, heart failure, and death in our study were of significance (OR 3.6, 95% CI 1.0-13.1, P = 0.04).
The results indicate that polymorphism at ACE2 gene is associated with male lone AF in a Chinese Han population. Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.
越来越多的流行病学证据表明，遗传因素可能使个体易患孤立性心房颤动（AF）。血管紧张素转换酶 2（ACE2）基因已被证实与高血压和左心室肥厚有关。我们的研究目的是探讨 ACE2 基因多态性与孤立性 AF 的关系。
共成功调查了 265 例连续的孤立性 AF 患者和 289 例健康对照者。采用聚合酶链反应（PCR）和直接测序法检测 ACE2 基因多态性 rs2106809 和 rs2285666。采用 Logistic 回归模型确定 ACE2 变异对孤立性 AF 的比值比（OR）和 95%置信区间（CI）。
在调整传统危险因素后，rs2106809 的 T 等位基因在男性中增加了患孤立性 AF 的风险（OR 1.24，95%CI 1.01-1.52，P=0.03）。男性 AF 患者与对照组之间 rs2285666 的 SNP 无显著差异。在女性孤立性 AF 人群中，两种多态性之间没有关联。在（36.3±4.5）个月的随访后，获得终点数据：死亡（心脏和非心脏）、缺血性卒中和心力衰竭。在男性亚组中，rs2106809 T 男性携带者与本研究中包括缺血性卒中和心力衰竭以及死亡在内的联合终点之间存在关联（OR 3.6，95%CI 1.0-13.1，P=0.04）。
结果表明，ACE2 基因多态性与中国汉族人群中的男性孤立性 AF 有关。携带 rs2106809 T 等位基因的孤立性 AF 男性与不良心脏事件有关。
