Corcoran J S, Owens C W, Yudkin J S
Clin Sci (Lond). 1987 Feb;72(2):225-32. doi: 10.1042/cs0720225.
A thermal clearance probe was used to measure fingertip blood flow. When flow was occluded the baseline value was reproducible (coefficient of variation 2% between subjects), whereas basal and maximum flow were poorly reproducible even within subjects. Synchronous changes in thermal clearance were seen when two probes were used on fingers and toes of different limbs (r = 0.77 - 0.97), in keeping with a central control mechanism. Fingertip blood flow, as measured by thermal clearance, correlated with Po2 of venous blood draining from the dorsum of the hand (r = 0.72 - 0.92). Contralateral hand cooling caused a sharp reduction of fingertip thermal clearance by 44.2 +/- 3.7%. Thermal clearance traces were damped in fingers with heavy keratinization, and improved when keratin was removed. Comparisons with venous occlusion plethysmography (VOP) and photoelectric plethysmography (PPG) showed that thermal clearance correlates with both methods (r = 0.60 - 0.92 for VOP and 0.64 - 0.93 for PPG) but with much integration of the signal and a 10 s lag. It is concluded that the probes used measure predominantly anastomotic flow and not nutrient skin blood flow alone.
使用热清除探头测量指尖血流量。当血流被阻断时，基线值具有可重复性（受试者之间的变异系数为2%），而基础血流量和最大血流量即使在受试者内部也难以重复。当在不同肢体的手指和脚趾上使用两个探头时，观察到热清除的同步变化（r = 0.77 - 0.97），这与中枢控制机制一致。通过热清除测量的指尖血流量与从手背引流的静脉血的氧分压相关（r = 0.72 - 0.92）。对侧手部冷却导致指尖热清除率急剧降低44.2 +/- 3.7%。在角化严重的手指中，热清除曲线受到抑制，去除角质后有所改善。与静脉阻塞体积描记法（VOP）和光电体积描记法（PPG）的比较表明，热清除与这两种方法均相关（VOP的r = 0.60 - 0.92，PPG的r = 0.64 - 0.93），但信号有较多整合且有10秒延迟。得出的结论是，所使用的探头主要测量吻合血流，而不仅仅是皮肤营养血流。
