Azarpeyvand Mahdi, Azarpeyvand Mohammad
Department of Engineering, University of Cambridge, Cambridge, United Kingdom.
Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.
Ultrasound Med Biol. 2014 Feb;40(2):422-33. doi: 10.1016/j.ultrasmedbio.2013.07.008. Epub 2013 Dec 15.
Acoustic manipulation of porous spherical shells, widely used as drug delivery carriers and magnetic resonance imaging contrast agents, is investigated analytically. The technique used for this purpose is based on the application of high-order Bessel beams as a single-beam acoustic manipulation device, by which particles lying on the axis of the beam can be pulled toward the beam source. The exerted acoustic radiation force is calculated using the standard partial-wave series method, and the wave propagation within the porous media is modeled using Biot's theory of poro-elasticity. Numerical simulations are performed for porous aluminum and silica shells of different thickness and porosity. Results indicate that manipulation of low-porosity shells is possible using Bessel beams with large conical angles, over a number of broadband frequency ranges, whereas manipulation of highly porous shells can occur over both narrowband and broadband frequency domains.
对广泛用作药物输送载体和磁共振成像造影剂的多孔球壳进行了声学操纵分析研究。用于此目的的技术基于应用高阶贝塞尔光束作为单束声学操纵装置，通过该装置，位于光束轴上的粒子可被拉向光束源。使用标准的分波级数法计算施加的声辐射力，并使用比奥多孔弹性理论对多孔介质内的波传播进行建模。对不同厚度和孔隙率的多孔铝壳和二氧化硅壳进行了数值模拟。结果表明，在多个宽带频率范围内，使用大锥角的贝塞尔光束可以操纵低孔隙率的壳，而对于高孔隙率的壳，在窄带和宽带频率域都可以进行操纵。
