应激蛋白Hsp27的表达可预测接受手术治疗的小细胞肺癌和大细胞神经内分泌癌患者的预后。
Stress protein Hsp27 expression predicts the outcome in operated small cell lung carcinoma and large cell neuroendocrine carcinoma patients.
作者信息
Marinova D M, Slavova Y G, Trifonova N, Kostadinov D, Maksimov V, Petrov D
机构信息
Department of Pneumology, University Hospital for Pulmonary Diseases "Saint Sofia", Medical University of Sofia, Bulgaria.
出版信息
J BUON. 2013 Oct-Dec;18(4):915-20.
PURPOSE
Heat shock protein (Hsp)27 is overexpressed in a range of human cancers and is implicated in tumor cell proliferation, differentiation, invasion, metastasis, and survival. The aim of the present study was to determine the prognostic significance of Hsp27 expression in small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC).
METHODS
Surgically resected SCLCs (N=51) and LCNECs (N=15) were studied. The Hsp27 expression was detected immunohistochemically.
RESULTS
Hsp27 positive immunoreaction in the cytoplasm was observed in 45 (88%) SCLCs and 14 (93%) LCNECs. A combination of cytoplasmic with nuclear Hsp27 expression was observed in 28 (62%) SCLCs and 14 (100%) LCNECs. There was a correlation between Hsp27 cytoplasmic overexpression and Hsp27 nuclear expression with patient survival confirmed by Cox multivariate analysis.
CONCLUSION
We conclude that the higher Hsp27 cytoplasmic expression and nuclear expression may represent favorable prognostic factors in SCLC and LCNEC.
目的
热休克蛋白（Hsp）27在多种人类癌症中过表达，并与肿瘤细胞的增殖、分化、侵袭、转移及存活有关。本研究旨在确定Hsp27表达在小细胞肺癌（SCLC）和大细胞神经内分泌癌（LCNEC）中的预后意义。
方法
对手术切除的51例SCLC和15例LCNEC进行研究。采用免疫组织化学法检测Hsp27表达。
结果
45例（88%）SCLC和14例（93%）LCNEC的细胞质中观察到Hsp27阳性免疫反应。28例（62%）SCLC和14例（100%）LCNEC观察到细胞质与细胞核Hsp27表达并存。Cox多因素分析证实，Hsp27细胞质过表达和细胞核表达与患者生存率之间存在相关性。
结论
我们得出结论，较高的Hsp27细胞质表达和细胞核表达可能是SCLC和LCNEC的有利预后因素。
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