Okyere Gabriel Asare, Alalbil Paul Awinbil, Ping-Naah Henry, Tifere Yakubu
Department of Statistics, Western Michigan University, Kalamazoo, MI, USA
Department of Mathematics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Int Assoc Provid AIDS Care. 2015 May-Jun;14(3):255-60. doi: 10.1177/2325957413500531. Epub 2013 Dec 16.
We describe the rate of death and identify the determinants of survival in a cohort of adults starting antiretroviral therapy (ART) in 2 hospitals in Upper West Region, Ghana. Kaplan-Meier model was used to estimate the survival probability after ART initiation and Cox proportional hazard model used to assess the relationship between baseline variables and mortality. A total of 91 clients who were initiated on ART in both hospitals participated in the study. Clients staged in the World Health Organization (WHO) clinical stage III/IV had a higher risk of mortality than those staging I/II (hazard ratio [HR] of 3.93). Hemoglobin value at baseline with a cutoff ≥12 g/dL for women (and ≥13 for men) was strongly associated with mortality in participants with an HR of 3.87 (95% confidence interval [CI]: 0.71-21.19) for severe anemia, 2.11 (95% CI: 0.45-9.93) for moderate anemia, and 0.88 (95% CI: 0.16-4.82) for mild anemia. Anemia and WHO staging were independent predictors of mortality.
我们描述了在加纳上西部地区两家医院开始接受抗逆转录病毒治疗（ART）的成年人群体中的死亡率，并确定了生存的决定因素。采用Kaplan-Meier模型估计开始接受ART后的生存概率，采用Cox比例风险模型评估基线变量与死亡率之间的关系。两家医院共有91名开始接受ART治疗的患者参与了该研究。世界卫生组织（WHO）临床分期为III/IV期的患者比I/II期患者的死亡风险更高（风险比[HR]为3.93）。基线血红蛋白值，女性临界值≥12 g/dL（男性≥13 g/dL）与参与者的死亡率密切相关，重度贫血的HR为3.87（95%置信区间[CI]：0.71-21.19），中度贫血为2.11（95% CI：0.45-9.93），轻度贫血为0.88（95% CI：0.16-4.82）。贫血和WHO分期是死亡率的独立预测因素。
