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激素:实证贡献。青少年人格障碍背景下的皮质醇反应性和恢复。

Hormones: empirical contribution. Cortisol reactivity and recovery in the context of adolescent personality disorder.

出版信息

J Pers Disord. 2014 Feb;28(1):25-39. doi: 10.1521/pedi.2014.28.1.25.

Abstract

The present study examined whether the associations between stress responses and psychopathology were moderated by adolescent personality disorder (PD) traits. Participants were a community sample of 106 adolescents (47 male, Mage = 16.01) and their parents. Parents reported on adolescents' PD traits and behavioral problems. Changes in salivary cortisol were assessed in response to a laboratory-based stress induction. Moderated regression analyses revealed significant linear and quadratic interactions between cortisol recovery and PD traits in the prediction of behavioral problems. Although typically conceptualized as "adaptive," steeper poststressor recovery was associated with more behavioral problems when PD traits were high. These findings suggest that, in the presence of maladaptive personality traits, premature recovery from environmental stressors may indicate an inability to respond appropriately to negative environmental stimuli, thus reflecting a core disturbance in PD trait functioning. The results underscore the informative role that personality plays in illuminating the nature of hormone functioning in adolescents and are interpreted in a developmental psychopathology framework.

摘要

本研究考察了青少年人格障碍(PD)特征是否调节了应激反应与精神病理学之间的关系。参与者是一个由 106 名青少年(47 名男性,Mage=16.01)及其父母组成的社区样本。父母报告了青少年的 PD 特征和行为问题。唾液皮质醇的变化是在基于实验室的应激诱导下评估的。调节回归分析显示,皮质醇恢复与 PD 特征在预测行为问题方面存在显著的线性和二次交互作用。尽管通常被概念化为“适应性”,但当 PD 特征较高时,应激后恢复较快与更多的行为问题相关。这些发现表明,在存在适应不良的人格特征的情况下,环境应激源的过早恢复可能表明无法对负面环境刺激做出适当反应,从而反映出 PD 特征功能的核心障碍。研究结果强调了人格在阐明青少年激素功能本质方面的重要作用,并在发展心理病理学框架下进行了解释。

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