Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan.
Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan.
Obes Res Clin Pract. 2010 Jul-Sep;4(3):e163-246. doi: 10.1016/j.orcp.2009.12.004.
We performed a 1-year follow-up study to determine the effects of smoking status and insulin resistance on the prevalence of metabolic syndrome.
This study included 2136 workers without metabolic syndrome at baseline who were followed for 1 year. The subjects were divided into four categories of smoking and work history, respectively. Insulin resistance was evaluated using the homeostasis model assessment for insulin resistance (HOMA-R).
The prevalence of metabolic syndrome after 1 year was 6.3%. A multiple logistic regression analysis showed that the current smokers category versus the non-smokers category, a 0.1-point increase in the HOMA-R score, a 1-point increase in the uric acid level, age, and body mass index were significantly correlated with increased odds for metabolic syndrome, yielding odds ratios (95% confidence intervals) of 1.61 (1.09-2.39), 1.14 (1.04-1.25), 1.31 (1.12-1.54), and 1.06 (1.03-1.09), and 1.23 (1.15-1.31), respectively.
Current smoking, insulin resistance, uric acid level, and age contributed positively to the prevalence of metabolic syndrome. In contrast, smoking cessation within 1 year and work history did not contribute to metabolic syndrome.
我们进行了为期 1 年的随访研究，以确定吸烟状况和胰岛素抵抗对代谢综合征患病率的影响。
本研究纳入了 2136 名基线时无代谢综合征的工人，随访 1 年。根据吸烟和工作史将受试者分为四组。采用稳态模型评估胰岛素抵抗（HOMA-R）评估胰岛素抵抗。
1 年后代谢综合征的患病率为 6.3%。多因素 logistic 回归分析显示，与不吸烟者相比，当前吸烟者、HOMA-R 评分增加 0.1 分、尿酸水平增加 1 分、年龄和体重指数与代谢综合征的患病风险增加显著相关，其比值比（95%置信区间）分别为 1.61（1.09-2.39）、1.14（1.04-1.25）、1.31（1.12-1.54）和 1.06（1.03-1.09）、1.23（1.15-1.31）。
当前吸烟、胰岛素抵抗、尿酸水平和年龄均与代谢综合征的患病率呈正相关。相比之下，1 年内戒烟和工作史与代谢综合征无关。
