Department of Biological Sciences, California State University, San Marcos, California, USA; Department of Biological Sciences, Palomar Community College, San Marcos, California, USA; Neuroscience Education Institute, Carlsbad, California, USA.
CNS Spectr. 2013 Dec;18 Suppl 1:45-53; quiz 54. doi: 10.1017/S109285291300076X.
Although not all individuals who work outside of standard daytime hours develop physical and psychiatric issues, there is a substantial portion of shift workers who develop shift work disorder. Shift work disorder is due to a misalignment between an individual's endogenous circadian rhythms and environmental stimuli, and can have potentially serious consequences to an individual's health and quality of life. This article reviews the neurobiological and genetic underpinnings of shift work disorder, and describes how desynchronization of the molecular clock may lead to both physical and psychiatric illnesses. Diagnostic tools and treatment guidelines to address the circadian misalignment, excessive sleepiness, and insomnia experienced by patients with shift work disorder are also discussed.
虽然并非所有在标准日间工作时间之外工作的人都会出现身体和精神问题，但相当一部分轮班工人会出现轮班工作障碍。轮班工作障碍是由于个体的内源性昼夜节律与环境刺激之间的不匹配引起的，可能会对个体的健康和生活质量产生潜在的严重后果。本文综述了轮班工作障碍的神经生物学和遗传学基础，并描述了分子钟的失同步如何导致身体和精神疾病。还讨论了用于解决轮班工作障碍患者所经历的昼夜节律失调、过度嗜睡和失眠的诊断工具和治疗指南。
