钙视网膜蛋白免疫组织化学染色是否减少先天性巨结肠症直肠活检的不确定诊断？
Does calretinin immunohistochemistry reduce inconclusive diagnosis in rectal biopsies for Hirschsprung disease?
机构信息
*Division of Pediatric Surgery, Department of Surgery †Department of Pathology, Botucatu Medical School, UNESP-Universidade Estadual Paulista, Botucatu-SP, Brazil.
出版信息
J Pediatr Gastroenterol Nutr. 2014 May;58(5):603-7. doi: 10.1097/MPG.0000000000000263.
Many difficulties occur during the evaluation of rectal biopsies for the diagnosis of Hirschsprung disease. We investigated whether the introduction of calretinin (CR) immunohistochemistry in a diagnostic panel could decrease the rate of inconclusive results. Data from 82 patients undergoing rectal biopsies before and after CR introduction were analyzed. Inconclusive results were obtained in 17 of 45 rectal biopsies (37.8%) in the series of cases before CR introduction and in 5 of 42 rectal biopsies (11.9%) in the series of cases after CR (P < 0.006). The inclusion of CR in the histopathologic panel may improve the diagnostic accuracy of Hirschsprung disease.
在评估直肠活检以诊断先天性巨结肠病时会遇到许多困难。我们研究了在诊断小组中引入钙视网膜蛋白（CR）免疫组织化学是否可以降低不确定结果的发生率。分析了在引入 CR 之前和之后接受直肠活检的 82 名患者的数据。在引入 CR 之前的 45 例直肠活检中，有 17 例（37.8%）结果不确定，而在引入 CR 之后的 42 例直肠活检中，有 5 例（11.9%）结果不确定（P < 0.006）。在组织病理学小组中纳入 CR 可能会提高先天性巨结肠病的诊断准确性。
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