Ahmann F R, Schifman R B
J Urol. 1987 Mar;137(3):431-4. doi: 10.1016/s0022-5347(17)44057-2.
Prostate specific antigen, prostatic acid phosphatase antigen and acid phosphatase activity were measured on 175 serum samples serially collected from 80 patients with metastatic stage D adenocarcinoma of the prostate. Prostate specific antigen and prostatic acid phosphatase antigen concentrations were measured with a monoclonal radioimmunometric assay, and acid phosphatase activity was measured enzymatically. The over-all frequency of abnormal levels of prostate specific antigen (76 per cent) was significantly greater than abnormal prostatic acid phosphatase antigen (60 per cent) and acid phosphatase activity (49 per cent) results (p less than 0.001). These differences were greater among the subset of patients in clinical remission. Levels greater than 10 times normal were observed in 68 per cent of prostate specific antigen, 43 per cent of prostatic acid phosphatase antigen and 31 per cent of acid phosphatase activity measurements (p less than 0.001). Three or more serial prostate specific antigen measurements in 17 patients demonstrated excellent correlation with independently assessed clinical disease activity. These results suggest that prostate specific antigen is a more sensitive and potentially more useful tumor marker than acid phosphatase measurements in patients with metastatic prostatic carcinoma.
对80例前列腺D期转移性腺癌患者连续采集的175份血清样本检测了前列腺特异性抗原、前列腺酸性磷酸酶抗原和酸性磷酸酶活性。采用单克隆放射免疫分析法检测前列腺特异性抗原和前列腺酸性磷酸酶抗原浓度，采用酶法检测酸性磷酸酶活性。前列腺特异性抗原水平异常的总体发生率（76%）显著高于前列腺酸性磷酸酶抗原（60%）和酸性磷酸酶活性（49%）异常结果（p<0.001）。这些差异在临床缓解的患者亚组中更大。在68%的前列腺特异性抗原、43%的前列腺酸性磷酸酶抗原和31%的酸性磷酸酶活性检测中观察到高于正常水平10倍以上的情况（p<0.001）。对17例患者进行的三次或更多次连续前列腺特异性抗原检测显示，与独立评估的临床疾病活动度具有良好的相关性。这些结果表明，在转移性前列腺癌患者中，前列腺特异性抗原是一种比酸性磷酸酶检测更敏感且可能更有用的肿瘤标志物。
