别嘌醇诱发红皮病。

Allopurinol induced erythroderma.

作者信息

Sharma Geeta, Govil Dinesh Chandra

机构信息

Departments of Dermatology and Dermatology and Venereology, Rama Medical College, Hospital and Research Centre, Mandhana, Kanpur, Uttar Pradesh, India.

出版信息

Indian J Pharmacol. 2013 Nov-Dec;45(6):627-8. doi: 10.4103/0253-7613.121381.

DOI:10.4103/0253-7613.121381

PMID:24347776

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3847258/

Abstract

Allopurinol, a widely prescribed urate lowering agent is responsible for various adverse drug reactions, including erythroderma. A 45-year-old male patient was admitted with the complaints of fever, redness and scaling all over the body after 3-4 weeks of allopurinol treatment for asymptomatic hyperuricemia. Elevated liver enzymes were detected in his blood analysis. Skin biopsy was consistent with drug induced erythroderma. Allopurinol was stopped and steroids were started. Patient improved over a period of 2 weeks.

摘要

别嘌醇是一种广泛使用的降尿酸药物，可引发包括红皮病在内的各种药物不良反应。一名45岁男性患者在接受别嘌醇治疗无症状高尿酸血症3 - 4周后，因全身发热、发红和脱屑前来就诊。血液分析显示其肝酶升高。皮肤活检结果符合药物性红皮病。停用别嘌醇并开始使用类固醇治疗。患者在2周内病情好转。