Benge Jared F, Phenis Richard A, Bernett Abigail, Cruz-Laureano Daniel, Kirmani Batool F
Department of Neurology, Scott & White Healthcare, Texas A&M Health Science Center College of Medicine , Temple, TX , USA.
Front Neurol. 2013 Dec 2;4:195. doi: 10.3389/fneur.2013.00195.
Moderate to severe traumatic brain injury (TBI) is one of the leading causes of acquired epilepsy. Prophylaxis for seizures is the standard of care for individuals with moderate to severe injuries at risk for developing seizures, though relatively limited comparative data is available to guide clinicians in their choice of agents. There have however been experimental studies which demonstrate potential neuroprotective qualities of levetiracetam after TBI, and in turn there is hope that eventually such agents may improve neurobehavioral outcomes post-TBI. This mini-review summarizes the available studies and suggests areas for future studies.
中重度创伤性脑损伤（TBI）是后天性癫痫的主要病因之一。对于有癫痫发作风险的中重度脑损伤患者，预防性使用抗癫痫药物是标准治疗方法，不过可供临床医生选择药物的比较数据相对有限。然而，已有实验研究表明左乙拉西坦在创伤性脑损伤后具有潜在的神经保护作用，因此人们希望这类药物最终可能改善创伤性脑损伤后的神经行为结果。本综述总结了现有研究，并提出了未来研究的方向。
