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Leksell伽玛刀：治疗尼尔森综合征罕见病例的有效非侵入性疗法。

Leksell Gamma Knife : An Effective Non Invasive Treatment for Rare Case of Nelson's Syndrome.

作者信息

Arshad Faheem, Laway Bashir Ahmad, Bhat Manzoor Ahmad, Irfan Showkat Hakim, Kotwal Suman, Ahmad Mir Shahnaz

机构信息

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences Soura, Resident Scholar Endocrinology, Srinagar, India.

出版信息

Int J Endocrinol Metab. 2013 Summer;11(3):195-8. doi: 10.5812/ijem.10225. Epub 2013 Jul 1.

DOI:10.5812/ijem.10225
PMID:24348593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3860107/
Abstract

Nelson's syndrome nowadays a rare entity results from an adrenocorticotropin (ACTH)-secreting pituitary adenoma in patients with refractory Cushing's disease after a therapeutic bilateral adrenal gland removal. We report a case of 25 year old female with cushing's disease who was initially managed with medical treatment, but in view of severe persistent hyper cortisol state was subjected to bilateral adrenalectomy following which she developed Nelson's syndrome after a gap of six years, which was difficult to diagnose because of limited investigations available. Patient was managed with stereotactic radiosurgery (gamma knife surgery).

摘要

尼尔森综合征如今是一种罕见病症，它由难治性库欣病患者在接受双侧肾上腺治疗性切除术后，垂体分泌促肾上腺皮质激素（ACTH）的腺瘤引发。我们报告一例25岁患有库欣病的女性病例，该患者最初接受药物治疗，但鉴于严重且持续的高皮质醇状态，接受了双侧肾上腺切除术，术后六年出现尼尔森综合征，由于可用的检查有限，该病难以诊断。患者接受了立体定向放射外科治疗（伽玛刀手术）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/abf252be69d8/ijem-11-195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/fd098e5a5d9f/ijem-11-195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/bfbc1374e767/ijem-11-195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/abf252be69d8/ijem-11-195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/fd098e5a5d9f/ijem-11-195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/bfbc1374e767/ijem-11-195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6c/3860107/abf252be69d8/ijem-11-195-g003.jpg

相似文献

1
Leksell Gamma Knife : An Effective Non Invasive Treatment for Rare Case of Nelson's Syndrome.Leksell伽玛刀：治疗尼尔森综合征罕见病例的有效非侵入性疗法。
Int J Endocrinol Metab. 2013 Summer;11(3):195-8. doi: 10.5812/ijem.10225. Epub 2013 Jul 1.
2
Stereotactic radiosurgery before bilateral adrenalectomy is associated with lowered risk of Nelson's syndrome in refractory Cushing's disease patients.双侧肾上腺切除术前行立体定向放射外科治疗可降低难治性库欣病患者发生纳尔逊综合征的风险。
Acta Neurochir (Wien). 2021 Jul;163(7):1949-1956. doi: 10.1007/s00701-021-04823-1. Epub 2021 Mar 24.
3
Gamma knife radiosurgery for Cushing's disease and Nelson's syndrome.伽玛刀放射外科治疗库欣病和尼尔森综合征。
Pituitary. 2015 Jun;18(3):376-84. doi: 10.1007/s11102-014-0584-7.
4
Gamma Knife surgery for adrenocorticotropic hormone-producing pituitary adenomas after bilateral adrenalectomy.双侧肾上腺切除术后垂体促肾上腺皮质激素腺瘤的伽玛刀手术
J Neurosurg. 2007 Jun;106(6):988-93. doi: 10.3171/jns.2007.106.6.988.
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Nelson's syndrome: a review of the clinical manifestations, pathophysiology, and treatment strategies.尼尔森综合征：临床表现、病理生理学及治疗策略综述
Neurosurg Focus. 2015 Feb;38(2):E14. doi: 10.3171/2014.10.FOCUS14681.
6
Corticotropin-releasing hormone (CRH) stimulation in Nelson's syndrome: response of adrenocorticotropin secretion to pulse injection and continuous infusion of CRH.尼尔森综合征中促肾上腺皮质激素释放激素（CRH）刺激：促肾上腺皮质激素分泌对CRH脉冲注射和持续输注的反应
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Electron microscopical morphometry of well-differentiated and undifferentiated ACTH secreting adenomas in Cushing's disease and Nelson's syndrome.库欣病和纳尔逊综合征中高分化及未分化促肾上腺皮质激素分泌腺瘤的电子显微镜形态计量学研究
Virchows Arch A Pathol Anat Histopathol. 1991;419(5):395-401. doi: 10.1007/BF01605073.
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Nelson's syndrome after Cushing's disease in childhood: a continuing problem.儿童库欣病后的纳尔逊综合征：一个持续存在的问题。
Surgery. 1984 Dec;96(6):1067-77.
9
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.与库欣病相比，尼尔森综合征患者的分泌突发量显著增加且促肾上腺皮质激素分泌过程异常规律。
Clin Endocrinol (Oxf). 2004 Jun;60(6):765-72. doi: 10.1111/j.1365-2265.2004.02052.x.
10
Gamma Knife radiosurgery for the treatment of Nelson's syndrome: a multicenter, international study.伽玛刀放射外科治疗尼尔森综合征：一项多中心国际研究。
J Neurosurg. 2019 Jul 12;133(2):336-341. doi: 10.3171/2019.4.JNS19273. Print 2020 Aug 1.

本文引用的文献

1
Nelson's syndrome.纳尔逊综合征。
Eur J Endocrinol. 2010 Oct;163(4):495-507. doi: 10.1530/EJE-10-0466. Epub 2010 Jul 28.
2
Treatment of Nelson's syndrome with temozolomide.替莫唑胺治疗纳尔逊综合征
Eur J Endocrinol. 2009 Jan;160(1):115-9. doi: 10.1530/EJE-08-0557. Epub 2008 Nov 4.
3
Nelson syndrome: comprehensive review of pathophysiology, diagnosis, and management.尼尔森综合征：病理生理学、诊断及管理的全面综述
Neurosurg Focus. 2007;23(3):E13. doi: 10.3171/foc.2007.23.3.15.
4
Gamma knife stereotactic radiosurgery for acromegaly.伽玛刀立体定向放射外科治疗肢端肥大症。
Eur J Endocrinol. 2007 Sep;157(3):255-63. doi: 10.1530/EJE-07-0189.
5
Corticotroph tumor progression after adrenalectomy in Cushing's Disease: A reappraisal of Nelson's Syndrome.库欣病肾上腺切除术后促肾上腺皮质激素肿瘤进展：对尼尔森综合征的重新评估。
J Clin Endocrinol Metab. 2007 Jan;92(1):172-9. doi: 10.1210/jc.2006-1328. Epub 2006 Oct 24.
6
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.与库欣病相比，尼尔森综合征患者的分泌突发量显著增加且促肾上腺皮质激素分泌过程异常规律。
Clin Endocrinol (Oxf). 2004 Jun;60(6):765-72. doi: 10.1111/j.1365-2265.2004.02052.x.
7
ACTH-producing tumor of the pituitary gland.垂体促肾上腺皮质激素分泌瘤
N Engl J Med. 1958 Jul 24;259(4):161-4. doi: 10.1056/NEJM195807242590403.
8
Neurosurgical treatment of Nelson's syndrome.尼尔森综合征的神经外科治疗。
J Clin Endocrinol Metab. 2002 Dec;87(12):5465-9. doi: 10.1210/jc.2002-020299.
9
Evaluation of surgically treated Nelson's syndrome.
Acta Neurochir (Wien). 1982;65(1-2):3-13. doi: 10.1007/BF01405437.