Zahavi I, Goldbourt U, Cohen-Mandelzweig L, Katz M, Appel S, Harel G, Sperling Z, Lazarovici M, Hart J, Neufeld H N
Prev Med. 1987 Jan;16(1):35-51. doi: 10.1016/0091-7435(87)90004-1.
To determine age and ethnic patterns of blood lipid levels in childhood and adolescence and to extend previous adult and late adolescent Israeli data to prepubertal ages, the levels of plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were determined among 1,153 schoolchildren in the area of Petah-Tikva. Half of the children were born to immigrants from Yemen. Among boys, TC levels progressively decreased as age increased from 10-11 to 14-15 years (159 to 142 mg/dl). The age-specific TC and HDL-C means among boys are compatible with an initial swift fall with age, followed by a rise restricted to TC during puberty. Among girls, progressively lower means through ages 12-13 and increasingly higher ones for older age groups are also compatible with puberty-determined changes, previously observed in American cohorts. The differences in TC were only partly accounted for by lower HDL-C means at higher ages (52 mg/dl in the youngest and 45 mg/dl in the oldest age group, respectively, among boys, compared with 53 mg/dl for girls at both ages 9 and 16-17). TG levels in boys, but not in girls, showed age differences paralleling those found for HDL-C, but in an inverse direction. TC means were lower as age increased only among female offspring of European-born Jews (159 to 148 mg/dl, ages 9-12 compared with ages 13-17), a phenomenon that requires further study. Overall, TC and HDL-C were clearly higher among girls than boys beginning at ages 12-13, with little or no sex differences in TG. The sex differences in TC, contrary to previous studies, were not fully accounted for by HDL-C sex differences. The ethnic variability paralleled previous findings in Israeli adults and adolescents, showing low TC levels among male offspring of Yemenite and other Asian-born fathers. The ethnic differences among girls were small. No specific pattern of age-related lipid changes was found in the group of Yemenite origin, who represented offspring of parents with notoriously low levels of coronary heart disease incidence.
为了确定儿童期和青少年期血脂水平的年龄和种族模式，并将以色列之前关于成年人和青少年晚期的数据扩展到青春期前年龄段，我们测定了佩塔提克瓦地区1153名学童的血浆总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平。一半的儿童是也门移民的后代。在男孩中，随着年龄从10 - 11岁增加到14 - 15岁，TC水平逐渐下降（从159毫克/分升降至142毫克/分升）。男孩中按年龄划分的TC和HDL-C均值符合随着年龄最初迅速下降，随后在青春期仅TC上升的情况。在女孩中，12 - 13岁期间均值逐渐降低，而年龄较大组均值逐渐升高，这也与之前在美国队列中观察到的由青春期决定的变化相符。TC的差异仅部分由较高年龄时较低的HDL-C均值所解释（男孩中最年轻年龄组为52毫克/分升，最年长年龄组为45毫克/分升，而女孩在9岁和16 - 17岁时均为53毫克/分升）。男孩的TG水平（而非女孩）显示出与HDL-C相似的年龄差异，但方向相反。仅在欧洲出生的犹太女性后代中，TC均值随着年龄增加而降低（9 - 12岁时为159毫克/分升，13 - 17岁时为148毫克/分升），这一现象需要进一步研究。总体而言，从12 - 13岁开始，女孩的TC和HDL-C明显高于男孩，TG几乎没有性别差异。与之前的研究相反，TC的性别差异并未完全由HDL-C的性别差异所解释。种族差异与以色列成年人和青少年之前的研究结果相似，也门和其他亚洲出生的父亲的男性后代TC水平较低。女孩中的种族差异较小。在代表冠心病发病率极低的父母后代的也门裔群体中，未发现与年龄相关的血脂变化的特定模式。
