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Dipole and Coulomb forces in electron capture dissociation and electron transfer dissociation mass spectroscopy.偶极和库仑力在电子俘获解离和电子转移解离质谱中的作用。
J Phys Chem A. 2012 Feb 23;116(7):1828-37. doi: 10.1021/jp210915c. Epub 2012 Feb 13.
2
The early life of a peptide cation-radical. Ground and excited-state trajectories of electron-based peptide dissociations during the first 330 femtoseconds.肽阳离子 - 自由基的早期生命。在最初的 330 飞秒内基于电子的肽解离的基态和激发态轨迹。
J Am Soc Mass Spectrom. 2012 Mar;23(3):446-59. doi: 10.1007/s13361-011-0283-9. Epub 2011 Dec 21.
3
Statistical analysis of electron transfer dissociation pairwise fragmentation patterns.电子转移解离成对碎片模式的统计分析。
Anal Chem. 2011 Dec 15;83(24):9540-5. doi: 10.1021/ac202327r. Epub 2011 Nov 28.
4
Protonation sites and dissociation mechanisms of t-butylcarbamates in tandem mass spectrometric assays for newborn screening.叔丁基氨基甲酸酯在新生儿筛查串联质谱分析中的质子化部位和离解机制。
J Mass Spectrom. 2011 Oct;46(10):1089-98. doi: 10.1002/jms.1993.
5
Dipole-guided electron capture causes abnormal dissociations of phosphorylated pentapeptides.偶极导向电子俘获导致磷酸化五肽的异常解离。
J Am Soc Mass Spectrom. 2011 Apr;22(4):731-51. doi: 10.1007/s13361-011-0083-2. Epub 2011 Feb 26.
6
On the relevance of peptide sequence permutations in shotgun proteomics studies.在鸟枪法蛋白质组学研究中肽序列排列的相关性。
J Proteome Res. 2011 May 6;10(5):2409-16. doi: 10.1021/pr101235w. Epub 2011 Apr 5.
7
Effect of the basic residue on the energetics, dynamics, and mechanisms of gas-phase fragmentation of protonated peptides.碱性残基对质子化肽气相碎裂的能量学、动力学和机制的影响。
J Am Chem Soc. 2010 Nov 17;132(45):16006-16. doi: 10.1021/ja104438z. Epub 2010 Oct 26.
8
The histidine effect. Electron transfer and capture cause different dissociations and rearrangements of histidine peptide cation-radicals.组氨酸效应。电子转移和俘获导致组氨酸肽正离子自由基发生不同的解离和重排。
J Am Chem Soc. 2010 Aug 11;132(31):10728-40. doi: 10.1021/ja907808h.
9
Analytical model for rates of electron attachment and intramolecular electron transfer in electron transfer dissociation mass spectrometry.电子转移解离质谱中电子俘获和分子内电子转移速率的分析模型。
J Am Chem Soc. 2010 May 26;132(20):7074-85. doi: 10.1021/ja100240f.
10
Backbone and side-chain specific dissociations of z ions from non-tryptic peptides.从非胰蛋白酶肽中锌离子的骨架和侧链特异性解离。
J Am Soc Mass Spectrom. 2010 Aug;21(8):1279-95. doi: 10.1016/j.jasms.2010.02.018. Epub 2010 Feb 18.

阳离子自由基在质谱分析中的复兴。

Renaissance of cation-radicals in mass spectrometry.

作者信息

Tureček František

机构信息

Department of Chemistry, Bagley Hall, University of Washington.

出版信息

Mass Spectrom (Tokyo). 2013;2(Spec Iss):S0003. doi: 10.5702/massspectrometry.S0003. Epub 2013 Apr 15.

DOI:10.5702/massspectrometry.S0003
PMID:24349922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3810458/
Abstract

This brief overview addresses the topic that was presented in the Thomson Medal Award session at the 19th International Mass Spectrometry Conference in Kyoto, Japan. Mass spectrometry of cation-radicals has enjoyed a remarkable renaissance thanks to the development of new methods for electron attachment to multiply charged peptide ions. The charge-reduced ions that are odd-electron species exhibit interesting reactivity that is useful for peptide and protein sequencing. The paper briefly reviews the fundamental aspects of the formation, energetics, and backbone dissociations of peptide cation-radicals.

摘要

本简要概述涉及在日本京都举行的第19届国际质谱会议上汤姆森奖章颁奖环节所提出的主题。由于用于附着电子到多电荷肽离子的新方法的发展，阳离子自由基的质谱分析迎来了显著的复兴。电荷减少的离子作为奇电子物种表现出有趣的反应活性，这对肽和蛋白质测序很有用。本文简要回顾了肽阳离子自由基的形成、能量学和主链解离的基本方面。