美国爱荷华州的研究表明，肥胖症和高血压相互作用会增加肾细胞癌的风险。
Obesity and hypertension interact to increase risk of renal cell carcinoma in Iowa, USA.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.
出版信息
Obes Res Clin Pract. 2007 May;1(2):I-II. doi: 10.1016/j.orcp.2007.02.004.
Renal cell carcinoma (RCC) rates in the US have risen, along with those of obesity and hypertension. We investigated the interactive relationship with obesity and hypertension (HT) through a population-based case-control study of RCC in Iowa consisting of 406 cases and 2434 controls. Data on height and weight at various ages and history of HT were collected and interaction tested by log-likelihood ratio tests. After adjustment, both obesity and HT were independently and interactively associated with increased RCC risk. Hypertensive subjects, obese (BMI ≥ 30) at age 40 were 4.2 (CI: 2.38-6.53) times more likely to develop RCC as normotensive individuals of normal weight (BMI < 25). A similar interactive pattern was observed for obesity at age 60 (p = 0.02). Interaction with obesity was more evident in women (pinteraction = 0.04 age 40, pinteraction = 0.01 age 60). Our findings suggest that maintaining body weight and/or controlling HT are strategies for preventing RCC.:
美国的肾细胞癌 (RCC) 发病率与肥胖症和高血压发病率一同上升。我们通过爱荷华州的一项基于人群的 RCC 病例对照研究，对肥胖症和高血压 (HT) 之间的相互关系进行了研究，该研究包括 406 例病例和 2434 例对照。收集了身高、体重和各年龄段的高血压病史等数据，并通过对数似然比检验进行了交互作用检验。经过调整，肥胖症和 HT 均与 RCC 风险增加独立且交互相关。与体重正常（BMI<25）的非高血压患者相比，肥胖症（BMI≥30）且 40 岁时患有高血压的高血压患者发生 RCC 的风险高 4.2 倍（95%CI：2.38-6.53）。在 60 岁时肥胖症（p=0.02）也观察到类似的交互模式。肥胖症与女性的相互作用更为明显（pinteraction=0.04，年龄 40；pinteraction=0.01，年龄 60）。我们的研究结果表明，保持体重和/或控制 HT 是预防 RCC 的策略。
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