对阿库氯铵的类过敏反应。

Anaphylactoid reaction to alcuronium.

作者信息

Pusey J M, Charlton S M, Skinner J B, Assem E S

出版信息

Anaesthesia. 1987 Feb;42(2):164-7. doi: 10.1111/j.1365-2044.1987.tb02991.x.

DOI:10.1111/j.1365-2044.1987.tb02991.x

Abstract

A 67-year-old woman suffered cardiovascular collapse during induction of anaesthesia. This was later shown to be anaphylactic in origin; the causative agent was alcuronium. In vitro testing showed a highly specific sensitivity to alcuronium with minimal cross-reactivity. Future anaesthesia with decreased risk was thereby assured. The clinical nature of this reaction and a review of the literature implicate the cardiovascular system as the principal target in this type of reaction to alcuronium and suggest that the heart is directly involved.

摘要

一名67岁女性在麻醉诱导过程中发生心血管虚脱。后来证明这是过敏性起源，致病剂是阿库氯铵。体外试验显示对阿库氯铵具有高度特异性敏感性，交叉反应极小。从而确保了未来麻醉风险降低。这种反应的临床性质以及文献综述表明，心血管系统是对阿库氯铵这类反应的主要靶点，并提示心脏直接受累。