局部照射后外周血白细胞和有核骨髓细胞的临床和实验观察。

Clinical and experimental observations of peripheral blood leukocytes and nucleated bone marrow cells after local irradiation.

机构信息

Department of Hematology, Jiangsu University Affiliated Xuzhou Hospital (Xuzhou Tumor Hospital), Xuzhou, China -

出版信息

Minerva Med. 2014 Feb;105(1):51-6. Epub 2013 Dec 18.

PMID:24351978

Abstract

AIM

Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia.

METHODS

For the human study, five cancer patients received local radiation therapy. Bone marrow aspiration was conducted to measure nucleated cell count and 99mTc-Sc sulfur colloid ECT imaging was carried out to examine bone marrow function. For the animal study, fifty New Zealand white rabbits were divided into 3 groups: non-irradiated control group (N.=10), abdomen irradiation group (irradiation area did not cover bone marrow) (N.=20), chest irradiation group (irradiation area covered bone marrow) (N.=20). Nucleated cell counts were taken after confirming onset of leukopenia.

RESULTS

Bone marrow of five patients proliferated normally. ECT imaging showed no abnormality in the pattern of red bone marrow distribution. Hematopoietic function was mildly active.

CONCLUSION

Suppressed myeloproliferative function does not fully account for irradiation-induced leukopenia.

摘要

目的

本研究旨在观察局部照射引起的骨髓损伤对白细胞减少症的影响。

方法

在人体研究中，五名癌症患者接受了局部放射治疗。进行骨髓抽吸以测量有核细胞计数，并进行 99mTc-Sc 硫胶体 ECT 成像以检查骨髓功能。在动物研究中，将五十只新西兰白兔分为三组：未照射对照组（N=10）、腹部照射组（照射面积不覆盖骨髓）（N=20）、胸部照射组（照射面积覆盖骨髓）（N=20）。在确认白细胞减少症发作后，进行有核细胞计数。