在 DMSO-HBr 体系中，由芳基甲基酮合成二芳基酰基硫翁溴化物。

Synthesis of dimethyl aryl acylsulfonium bromides from aryl methyl ketones in a DMSO-HBr system.

机构信息

Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, China.

出版信息

Molecules. 2013 Dec 16;18(12):15717-23. doi: 10.3390/molecules181215717.

DOI:10.3390/molecules181215717

PMID:24352024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269961/

Abstract

A new, simplified method for the synthesis of dimethyl aryl acylsulfonium salts has been developed. A series of dimethyl aryl acylsulfonium bromides were prepared by the reaction of aryl methyl ketones with hydrobromic acid and dimethylsulfoxide (DMSO). This sulfonium salt confirms that bromine production and the bromination reaction take place in the DMSO-HBr oxidation system. What's more, it is also a key intermediate for the synthesis of arylglyoxals.

摘要

一种新的、简化的二芳基酰基硫翁盐的合成方法已经被开发出来。通过芳基甲基酮与氢溴酸和二甲基亚砜（DMSO）的反应，制备了一系列二芳基酰基溴化硫翁盐。该硫翁盐证实了溴的生成和溴化反应发生在 DMSO-HBr 氧化体系中。此外，它还是芳基乙二醛合成的关键中间体。