Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
J Invest Dermatol. 2014 Jan;134(1):14-16. doi: 10.1038/jid.2013.372.
The acquisition of invasive properties in melanoma is associated with a high proclivity for metastasis, but the underlying pathways are poorly characterized. The Hippo pathway has an important role in organ size control and is dysregulated in some type of tumors. The present study, "Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma" by Nallet-Staub et al., 2013, provides the first in-depth analysis of expression of the Hippo pathway effectors YAP (yes-associated protein) and TAZ (Tafazzin) in human melanocytic lesions. Importantly, results from this study demonstrate a causal relationship between YAP/TAZ levels and melanoma cell tumorigenicity and invasiveness.
黑色素瘤侵袭性的获得与其高转移倾向相关，但潜在途径尚不清楚。 Hippo 通路在器官大小控制中具有重要作用，并且在某些类型的肿瘤中失调。 本研究“ Hippo 通路效应物 YAP 和 TAZ 在皮肤黑色素瘤中的侵袭前活性”，由 Nallet-Staub 等人于 2013 年进行，首次深入分析了 Hippo 通路效应物 YAP（yes-associated protein）和 TAZ（Tafazzin）在人类黑色素细胞病变中的表达。 重要的是，该研究的结果表明 YAP/TAZ 水平与黑色素瘤细胞的致瘤性和侵袭性之间存在因果关系。
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