Laboratory of Epidemiology, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Sciences, 666 Liuying West Road, Changchun, 130122, Jilin, China.
Arch Virol. 2014 Jun;159(6):1481-6. doi: 10.1007/s00705-013-1941-y. Epub 2013 Dec 19.
A canine rabies virus, Shaanxi-HZ-6, was isolated in Shaanxi Province, China, in 2009. Its genome has been completely sequenced and found to be closely related to the China I rabies virus strains widely circulating in China. The genomic length was 11,923 base pairs, and the overall organization of the genome was similar to that of other rabies virus isolates. Compared with isolates CQ92 and J, 84 amino acid substitutions (7 in the N gene, 15 in P, 6 in M, 25 in G, 31 in L) were observed in strain Shaanxi-HZ-6. Amino acid substitutions of R264H and V332I were noted in the G protein antigenic site I and site III, respectively. Residue 333 of the G protein, which is considered to be associated with pathogenicity, was Arg in Shaanxi-HZ-6. These and other substitutions may help provide an explanation why the China I lineage strain maintains its prevalence in China.
2009 年，在中国陕西省分离到一株犬狂犬病病毒，命名为陕西 HZ-6 株。其基因组已被完全测序，并发现与在中国广泛流行的中国 I 型狂犬病病毒株密切相关。基因组全长为 11923 个碱基对，基因组的整体结构与其他狂犬病病毒分离株相似。与 CQ92 和 J 株相比，在陕西 HZ-6 株中观察到 84 个氨基酸替换（N 基因 7 个，P 基因 15 个，M 基因 6 个，G 基因 25 个，L 基因 31 个）。在 G 蛋白抗原位点 I 和 III 中分别观察到 R264H 和 V332I 氨基酸替换。被认为与致病性相关的 G 蛋白 333 位氨基酸为精氨酸。这些和其他替换可能有助于解释为什么中国 I 谱系毒株在中国仍然流行。
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