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乌干达狂犬病病毒分离株的分子流行病学。

Molecular epidemiology of rabies virus isolates in Uganda.

机构信息

Nihon University Veterinary Research Center, 1866 Kameino, Fujisawa 252-8510, Kanagawa, Japan.

出版信息

Virus Res. 2010 Jan;147(1):135-8. doi: 10.1016/j.virusres.2009.10.003. Epub 2009 Oct 26.

Abstract

African field rabies virus isolates from domestic animals can be phylogenetically divided into three geographic lineages: Africa 1a (North and West Africa); Africa 1b (East and South Africa); Africa 2 (West Africa). Partial nucleotide sequences of the rabies virus nucleoprotein gene (203-nt) were obtained from five dogs and three goats in Uganda. The analyzed Ugandan field rabies viruses were categorized into the Africa 1a and Africa 1b lineages. The present study thus demonstrates that two African lineage-derived rabies viruses coexist in Uganda, which is located in the geographical region between the known Africa 1a and Africa 1b lineage distributions.

摘要

从家畜中分离到的非洲野狂犬病病毒可分为三个地理谱系

非洲 1a(北非和西非);非洲 1b(东非和南非);非洲 2(西非)。从乌干达的五只狗和三只山羊中获得了狂犬病病毒核蛋白基因(203-nt)的部分核苷酸序列。分析表明,乌干达的野狂犬病病毒属于非洲 1a 和 1b 谱系。本研究表明,在位于已知的非洲 1a 和 1b 谱系分布区之间的地理位置上,乌干达同时存在两种源自非洲谱系的狂犬病病毒。

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